An uncommon granulocytic sarcoma of the breast: a case report and literature review

Zhai, Jie; Kong, Xiangyi; Yang, Xue; Gao, Jun; Xuan, Lixue; Wang, Xiang; Wang, Jing; Fang, Yi

doi:10.2147/ott.s149149

Cited by 9 publications

(19 citation statements)

References 19 publications

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“…Myeloid sarcoma usually manifests concurrently or following the diagnosis of AML, chronic myeloid leukemia, myeloproliferative diseases, or myelodysplastic syndrome [13], and the presence of AML commonly and typically induces or predisposes a person to the development of myeloid sarcoma [4]. However, under rare circumstances, myeloid sarcoma can occur as an isolated extramedullary mass without a previous or concurrent diagnosis of AML (no evidence of peripheral blood or bone marrow involvement at the time of diagnosis) [1,13].…”

Section: Discussionmentioning

confidence: 99%

“…Myeloid sarcomas comprise myeloid cells with variable degrees of maturation and usually manifest simultaneously with or subsequently to the diagnosis of myeloid leukemia [3]. Premature cells that are differentiated from hematopoietic precursor cells interact with fibroblasts to induce myeloid metaplasia in nonhematopoietic tissues [4]. Breasts are rarely sites of myeloid sarcoma involvement [4].…”

Section: Introductionmentioning

confidence: 99%

“…Premature cells that are differentiated from hematopoietic precursor cells interact with fibroblasts to induce myeloid metaplasia in nonhematopoietic tissues [4]. Breasts are rarely sites of myeloid sarcoma involvement [4]. Few studies have reported on the radiologic features of breast myeloid sarcoma [4].…”

Section: Introductionmentioning

confidence: 99%

“…Breasts are rarely sites of myeloid sarcoma involvement [4]. Few studies have reported on the radiologic features of breast myeloid sarcoma [4].…”

Section: Introductionmentioning

confidence: 99%

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Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Kim

2019

Am J Case Rep

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Patient: Female, 24 Final Diagnosis: Myeloid sarcoma of the breast Symptoms: Breast lump Medication: — Clinical Procedure: Core needle biopsy Specialty: Radiology Objective: Rare disease Background: Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before, concurrently with, or following acute myeloid leukemia presentation. Few reports have focused on the imaging findings in cases of myeloid sarcoma of the breast, and the existing findings are variable and nonspecific; the present case report aimed to bridge this gap. Case Report: A 24-year-old female presented with a palpable lump at the upper outer quadrant of her right breast. She had noticed the mass 2 days prior to presentation. She was first diagnosed with acute myelogenous leukemia 18 months before the lump presentation and had undergone haploidentical stem cell transplantation 6 months prior. At the time of the breast lump presentation, she was undergoing chemotherapy for relapsed acute myeloid leukemia. Ultrasonography of her right breast revealed a circumscribed, oval mass corresponding to the palpable lump. Ultrasonography-guided 14-gauge core needle biopsy was performed on the breast mass, leading to a pathological diagnosis of myeloid sarcoma. Conclusions: We reported a case of myeloid sarcoma involving the breast. On sonography, although the internal echotexture resembled that of breast hamartoma, the observed hard elasticity and high vascularity raised suspicions of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Breasts are rarely sites of myeloid sarcoma involvement [4]. Few studies have reported on the radiologic features of breast myeloid sarcoma [4].…”

Section: Introductionmentioning

confidence: 99%

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Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Kim

2019

Am J Case Rep

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“…The localisation can be highly variable with soft tissues in predilection but also lymph nodes, bone, epidural region and viscera are possible [3,4]. The diagnosis is challenging.…”

Section: Introductionmentioning

confidence: 99%

Granulocytic Sarcoma with Meningeal Leukemia. A Case Report

Krisztián¹,

Péter²,

Arian³

et al. 2020

RCO

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The case of a 63-year-old woman is presented who developed 18 years after undergoing allogenic bone marrow transplantation for chronic myeloid leukaemia a granulocytic sarcoma localised in the presacral region. Complete radiologic remission was obtained with the administration of imatinib. She developed a metachron granulocytic sarcoma in the right frontal region associated to leptomeningeal infiltration. Complete clinical and near complete radiological remission was obtained with the administration of nilotinib. The patient was finally lost of progression of the frontal and meningeal localisations 45 months after the presentation of the first presacral lesion. Throughout the follow-up no sign of systemic leukaemia was detected.

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