An uncommon overlap of two common rheumatological disorders

Guleria, Sandesh; Jindal, Ankur Kumar; Pilania, Rakesh Kumar; Bhattarai, Dharmagat; Kaur, Amanpreet; Naganur, Sanjeev; Vignesh, Pandiarajan; Suri, Deepti; Singh, Surjit

doi:10.1177/0961203320930101

Cited by 1 publication

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“…These include fever, lymphadenopathy, arthritis or arthralgia, ocular and mucosal manifestations, rash, and multisystemic involvement. In addition, there appears to be a strong interplay between immunological and genetic factors in the pathogenesis of both KD and SLE ( Guleria et al, 2020 ; Saez-de-Ocariz et al, 2020 ). ITGAM (Integrin αM) was one such gene with the second highest degree of nodes (44) in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Exploration of Potential Biomarker Genes and Pathways in Kawasaki Disease: An Integrated in-Silico Approach

et al. 2022

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Kawasaki disease (KD) is a common childhood systemic vasculitis with a special predilection for coronary arteries. Even after more than five decades of the initial description of the disease, the etiology of KD remains an enigma. This transcriptome data re-analysis study aimed to elucidate the underlying pathogenesis of KD using a bioinformatic approach to identify differentially expressed genes (DEGs) to delineate common pathways involved in KD. Array datasets from the Gene Expression Omnibus database were extracted and subjected to comparative meta-analysis for the identification of prominent DEGs. Fifteen hub genes with high connectivity were selected from these DEGs (IL1B, ITGAM, TLR2, CXCL8, SPI1, S100A12, MMP9, PRF1, TLR8, TREM1, CD44, UBB, FCER1G, IL7R, and FCGR1A). Of these 15 genes, five genes (CXCL8, FCGR1A, IL1B, TLR2, and TLR8) were found to be involved in neutrophil degranulation. To gain further insight into the molecular mechanism, a protein–protein network was established. Significantly enriched pathways based on the above-mentioned genes were mainly centered on biological regulation and signaling events. In addition, the pathway analysis also indicated that the majority of the DEGs in KD were enriched in systemic lupus erythematosus, suggesting a strong interplay between immunological and genetic factors in the pathogenesis of KD. These findings could significantly aid in identifying therapeutic targets and understanding KD biosignatures to design a biomarker panel for early diagnosis and severity of the disease.

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Section: Discussionmentioning

confidence: 99%