An Uncommon ST1224 NDM-1-Producing &lt;b&gt;&lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;&lt;/b&gt; Isolated from the Bloodstream of a Leukemia Patient in China

Zhang, Xiaoxiao; Du, Jia; Zhou, Chen; Cao, Jianming; Lü, Hong; Liu, Haiyang; Bi, Wenzi; Zhou, Tieli

doi:10.1159/000469699

Cited by 5 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our investigation, PCR confirmed that the NDM-1-producing E. coli harbored quinolone resistance gene B ( qnrB ) and bla CTXM-9 . This result was similar to the other reports on strains carrying bla NDM-1 that also harbored other β-lactamase genes [ 18 ].…”

Section: Discussionsupporting

confidence: 92%

New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

et al. 2021

View full text Add to dashboard Cite

Background Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae. Case presentation In this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae were collected over the course of 2 years from two medical centers in Tehran, Iran. Production of carbapenemase was detected in the isolates using modified Hodge test. New Delhi metallo-beta-lactamase-1 genes were detected by polymerase chain reaction amplification with specific primers. Two New Delhi metallo-beta-lactamase-1-producing Escherichia coli strains were isolated from two Iranian patients with leukemia. These two patients were 6 and 15 years old, one female and the other male, from two oncology centers in Iran. The isolates were resistant to carbapenems (imipenem, meropenem), and two isolates were positive for carbapenemase production by modified Hodge test. Conclusions The emergence of New Delhi metallo-beta-lactamase-1-producing Escherichia coli is a threat for leukemia patients in oncology and hematology departments. We conclude that the incidence of multidrug resistant pathogens has increased among patients with leukemia and is life threatening.

show abstract

Section: Discussionsupporting

confidence: 92%

New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This result was similar to the other reports on strains carrying blaNDM-1 which also harbored other β-lactamase genes (2).…”

supporting

confidence: 92%

“…In a study conducted in China, the presence of this gene was rst reported in a patient with leukemia, especially in patients with neutropenia (2) .our study is also the rst report in Iran. The purpose of this study was to investigate the existence of NDM1 gens as a risk factor for life-threatening infection in patients with leukemia patients.…”

Section: Introductionsupporting

confidence: 62%

First Report of New Delhi Metallo-β-Lactamase-1 (NDM-1) Among Escherichia Coli Strains Isolated from Leukemia Patients in Iran

Roshani¹,

Goodarzi²,

Dehbashi³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in Patients with immunodeficiency particularly in leukemia patients. New Delhi metallo-β-lactamase (NDM-1) is an enzyme that class of beta-lactam antibiotics and is used in treatment of multi-drug resistant (MDR) infections. Case Presentation: In this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae collected over the course of two years from two medical centers of Tehran, Iran. Production of carbapenemase was detected of the isolates using MHT. New Delhi metallo-beta-lactamase 1 (blaNDM-1) genes were detected by polymerase chain reaction (PCR) ampliﬁcation with speciﬁc primers 2 blaNDM-1 producing E.coli strains were isolated from 2 leukemia of patients, The isolates were resistant to carbapenems (imipenem, meropenem),two isolates were positive for carbapenemase production by Modified Hodge test.Conclusions: The emerging of NDM-1 producing E. coli is a threat for leukemia patients in Oncology and hematology departments. We concluded that the incidence of MDR pathogens increased amang patients with leukemia and is life threatening.

show abstract

“…The NDM-1 gene is carried by a transferable plasmid of approximately 55 kb. 27 Six NDM-1-DHA1-ST1224 strains were detected in this study. PFGE analysis showed that those six strains exhibited homology and were epidemic strains in 2017.…”

Section: Discussionmentioning

confidence: 63%

<p>Epidemic Characteristics of Carbapenem-Resistant <em>Klebsiella pneumoniae</em> in the Pediatric Intensive Care Unit of Yanbian University Hospital, China</p>

Jin¹,

Shi²,

Jiang³

et al. 2020

IDR

View full text Add to dashboard Cite

Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) pose a serious threat to clinical patient management and public health, as they are generally resistant to most antibiotics and cause infections with high mortality rates. Klebsiella pneumoniae ranks second among Enterobacteriaceae species that cause nosocomial infections. In this study, we investigated the epidemic characteristics of carbapenem-resistant K. pneumoniae (CRKP) in the pediatric intensive care unit (PICU) of Yanbian University Hospital. Materials and Methods: A total of 14 non-duplicate CRKP strains, collected from March 2015 to November 2019, were subjected to automated microbial identification and antimicrobial susceptibility tests using the Phoenix-100 ID/AST system. The strains were also subjected to genotypic resistance testing, polymerase chain reaction assays to detect genes encoding carbapenemases and other β-lactamases, multi-locus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE)-based homology analysis. Results: Two carbapenemase genes, KPC-2 and NDM-1 (in eight and six strains, respectively), were detected. MLST enabled the division of the strains into two sequence types, ST11 and ST1224 (containing eight and six strains, respectively). PFGE results classified the 14 strains into clonotypes AD , of which clonotypes A and B belonged to ST11, while clonotypes C and D belonged to ST1224. Conclusion: Our study reveals that epidemics of the KPC-2-ST11 and NDM-1-ST1224 strains occurred in the PICU of Yanbian University Hospital. Surveillance and strict implementation of prevention and control measures are crucial to prevent the occurrence and rapid spread of nosocomial infections.

show abstract

An Uncommon ST1224 NDM-1-Producing <b><i>Klebsiella pneumoniae</i></b> Isolated from the Bloodstream of a Leukemia Patient in China

Cited by 5 publications

References 18 publications

New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

First Report of New Delhi Metallo-β-Lactamase-1 (NDM-1) Among Escherichia Coli Strains Isolated from Leukemia Patients in Iran

<p>Epidemic Characteristics of Carbapenem-Resistant <em>Klebsiella pneumoniae</em> in the Pediatric Intensive Care Unit of Yanbian University Hospital, China</p>

Contact Info

Product

Resources

About