An Unexpected Myxofibrosarcoma Seen on Ultrasound of the Knee

Hughes, Tudor; Fraiser, Ryan; Eastman, Amelia

doi:10.1093/pm/pnab028

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…An interesting case of MFS presented a Pancoast tumor-like manifestation with upper extremity pain, hand muscle atrophy, and Horner`s syndrome [ 37 ]. It can also present as pain in the knee joint [ 38 ]. There are rare reports of bilateral metachronous myxofibrosarcomas [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Giant Myxofibrosarcoma in the Lower Limb: An Overview of Diagnostic and Clinical Management

Ene,

Dimitriu,

Peride

et al. 2024

Diagnostics

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Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, is one of the undifferentiated pleomorphic sarcomas; it has a low incidence, affecting people in the sixth to eighth decades of life. It usually involves the extremities and is painless with a slow-growing pattern. Based on the case of a 52-year-old female patient who presented with a painful, massive, rapid-growing, ulcerated tumor of the anterior surface of the left thigh, we performed a literature review regarding the current standard of care for patients with MFS. Computed tomography examination, followed by magnetic resonance imaging and surgical biopsy with histopathological examination, confirmed the diagnosis and the presence of lung and inguinal lymph node metastases. Due to the rapid-growing pattern and the local aggressiveness, our tumor board team recommended emergency excisional surgery, with subsequent reconstructive procedures followed by referral to an oncological center. This review emphasizes the importance of proper and rapid diagnosis, followed by multidisciplinary management, for MFS cases with atypical presentation and distal metastases to improve overall outcomes.

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