2024
DOI: 10.1038/s41368-024-00323-x
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An unexpected role of Nogo-A as regulator of tooth enamel formation

Pierfrancesco Pagella,
Chai Foong Lai,
Laurence Pirenne
et al.

Abstract: Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical trials aiming at promoting the regeneration of the central nervous system upon traumatic and ischemic injury. In this work, we investigated the functions of Nogo-A during tooth development to determine its role in dental physiology and pathology. Using immunohistochemistry and in situ hybridization techniques, we showed that Nogo-A is highly expressed in the developing mouse teeth and, mos… Show more

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