As the volume of remotely sensed data grows significantly, content-based image retrieval (CBIR) becomes increasingly important, especially for cloud computing platforms that facilitate processing and storing big data in a parallel and distributed way. This paper proposes a novel parallel CBIR system for hyperspectral image (HSI) repository on cloud computing platforms under the guide of unmixed spectral information, i.e., endmembers and their associated fractional abundances, to retrieve hyperspectral scenes. However, existing unmixing methods would suffer extremely high computational burden when extracting meta-data from large-scale HSI data. To address this limitation, we implement a distributed and parallel unmixing method that operates on cloud computing platforms in parallel for accelerating the unmixing processing flow. In addition, we implement a global standard distributed HSI repository equipped with a large spectral library in a software-as-a-service mode, providing users with HSI storage, management, and retrieval services through web interfaces. Furthermore, the parallel implementation of unmixing processing is incorporated into the CBIR system to establish the parallel unmixing-based content retrieval system. The performance of our proposed parallel CBIR system was verified in terms of both unmixing efficiency and accuracy.