An unmodified gold nanorods-based DNA colorimetric biosensor with enzyme-free hybridization chain reaction amplification

Xu, Chengnan; Lan, Lingyi; Yao, Yao; Ping, Jianfeng; Li, Yanbin; Ying, Yibin

doi:10.1016/j.snb.2018.06.035

Cited by 47 publications

(17 citation statements)

References 38 publications

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“…In most cases, the concentrations of molecular biomarkers are found in picomolar levels in healthy individuals; therefore, these markers are undetectable by cross-linking aggregation. To improve the sensing performance, various signal amplification methods have been rationally designed and combined with the cross-linking aggregation, including enzyme-aided signal amplification (e.g., exonuclease [54,55], nicking endonucleases [56,57], and polymerases [41,58]) and enzyme-free amplification (e.g., hybridization chain reaction [59,60] and catalytic hairpin assembly [61,62]) strategies. With the use of these amplification approaches, the sensitivity has reached the required levels of sensitivity and enabled picomolar and even attomolar detection capabilities for satisfactory diagnostic tests.…”

Section: Aggregation-based Colorimetric Assaysmentioning

confidence: 99%

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

et al. 2019

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Gold nanoparticles are popularly used in biological and chemical sensors and their applications owing to their fascinating chemical, optical, and catalytic properties. Particularly, the use of gold nanoparticles is widespread in colorimetric assays because of their simple, cost-effective fabrication, and ease of use. More importantly, the gold nanoparticle sensor response is a visual change in color, which allows easy interpretation of results. Therefore, many studies of gold nanoparticle-based colorimetric methods have been reported, and some review articles published over the past years. Most reviews focus exclusively on a single gold nanoparticle-based colorimetric technique for one analyte of interest. In this review, we focus on the current developments in different colorimetric assay designs for the sensing of various chemical and biological samples. We summarize and classify the sensing strategies and mechanism analyses of gold nanoparticle-based detection. Additionally, typical examples of recently developed gold nanoparticle-based colorimetric methods and their applications in the detection of various analytes are presented and discussed comprehensively.

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Section: Aggregation-based Colorimetric Assaysmentioning

confidence: 99%

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

et al. 2019

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“…Gold nanorods (AuNRs) have attracted many researchers in the recent two decades because of their special characteristics and wide applications, including chemical and biological sensing, 1 − 3 surface-enhanced Raman scattering (SERS), 4 − 6 anticancer therapy, 7 − 9 and imaging. 10 − 12 Optically, the interaction of free electrons with light at different wavelengths leads to the localized surface plasmon resonance (LSPR) effect.…”

Section: Introductionmentioning

confidence: 99%

Seed-Mediated Synthesis of Gold Nanorods at Low Concentrations of CTAB

et al. 2021

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Although gold nanorods capped with hexadecyltrimethylammonium bromide (CTAB) have been prepared through the seed-mediated method for their use in diagnostics and therapeutics, the toxicity of AuNRs@CTAB limits their practical applications in the biomedical field. In this work, the synthesis and tuning of gold nanorods at very low concentrations of CTAB (as low as 0.008 M) was successfully achieved by using the seed-mediated method. Furthermore, we managed to optimize the growth conditions by changing the amount of seeds, AgNO 3 , and/or HCl. At low CTAB concentrations, gold nanorods with tunable size and aspect ratio, high monodispersity, and high purity were obtained and studied by UV–vis spectroscopy, transmission electron microscopy, and Mie–Gans theoretical calculations. This work revealed a method of nanoparticle growth that may be extended to synthesize other nanomaterials such as Ag, Cu, Pd, and Pt at such low CTAB concentrations.

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“…Nanorods, with high aspect ratios, constitute one of the most widely investigated materials for the fabrication of LSPR transducers. Unmodified gold nanorods (AuNRs) of 50 nm length have been used for deoxyribonucleic acid (DNA) detection down to 1.47 nM with a colorimetric sensor [96]. Wang et al studied telomerase activity in as low as 15 HeLa cells using the AuNR (70 nm length in absence of HeLa cells) etching strategy [97].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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An unmodified gold nanorods-based DNA colorimetric biosensor with enzyme-free hybridization chain reaction amplification

Cited by 47 publications

References 38 publications

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

Seed-Mediated Synthesis of Gold Nanorods at Low Concentrations of CTAB

Recent Progress in Optical Sensors for Biomedical Diagnostics

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