An Unprecedented Medium-Chain Diunsaturated N-acylhomoserine Lactone from Marine Roseobacter Group Bacteria

Ziesche, Lisa; Wolter, Laura; Wang, Hui; Pohlner, Marion; Engelen, Bert; Wagner‐Döbler, Irene; Schulz, Stefan

doi:10.3390/md17010020

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…Much research has been devoted to identifying AHLs from marine bacteria, and their effects on microalgae are varied and often subtle. AHLs are frequently isolated from microalgae-associated bacteria, and these bacteria often produce a diverse array of AHLs [ 25 , 40 , 41 ]. For example, Ziesche et al conducted a chemical survey of marine Roseobacter isolates, identifying a wide variety of AHLs.…”

Section: Direct Effects Of Quorum-sensing Signals On Microalgal Growth and Metabolismmentioning

confidence: 99%

How Do Quorum-Sensing Signals Mediate Algae–Bacteria Interactions?

Dow

2021

Microorganisms

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Quorum sensing (QS) describes a process by which bacteria can sense the local cell density of their own species, thus enabling them to coordinate gene expression and physiological processes on a community-wide scale. Small molecules called autoinducers or QS signals, which act as intraspecies signals, mediate quorum sensing. As our knowledge of QS has progressed, so too has our understanding of the structural diversity of QS signals, along with the diversity of bacteria conducting QS and the range of ecosystems in which QS takes place. It is now also clear that QS signals are more than just intraspecies signals. QS signals mediate interactions between species of prokaryotes, and between prokaryotes and eukaryotes. In recent years, our understanding of QS signals as mediators of algae–bacteria interactions has advanced such that we are beginning to develop a mechanistic understanding of their effects. This review will summarize the recent efforts to understand how different classes of QS signals contribute to the interactions between planktonic microalgae and bacteria in our oceans, primarily N-acyl-homoserine lactones, their degradation products of tetramic acids, and 2-alkyl-4-quinolones. In particular, this review will discuss the ways in which QS signals alter microalgae growth and metabolism, namely as direct effectors of photosynthesis, regulators of the cell cycle, and as modulators of other algicidal mechanisms. Furthermore, the contribution of QS signals to nutrient acquisition is discussed, and finally, how microalgae can modulate these small molecules to dampen their effects.

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Section: Direct Effects Of Quorum-sensing Signals On Microalgal Growth and Metabolismmentioning

confidence: 99%

How Do Quorum-Sensing Signals Mediate Algae–Bacteria Interactions?

Dow

2021

Microorganisms

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“…The gas chromatograph was programmed accordingly: 50°C (5 min isothermal), increasing with 5°C min –1 to 320°C, and operated in splitless mode. The positions of double-bonds were confirmed by DMDS derivatization as described ( Neumann et al, 2013 ; Ziesche et al, 2019 ).…”

Section: Phylogenetic Analysis and Taxonomic Identificationmentioning

confidence: 99%

High Potential for Secondary Metabolite Production of Paracoccus marcusii CP157, Isolated From the Crustacean Cancer pagurus

et al. 2021

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Secondary metabolites are key components in microbial ecology by mediating interactions between bacteria and their environment, neighboring species or host organisms. Bioactivities can be beneficial for both interaction partners or provide a competitive advantage only for the producer. Colonizers of confined habitats such as biofilms are known as prolific producers of a great number of bioactive secondary metabolites and are a potential source for novel compounds. We investigated the strain Paracoccus marcusii CP157, which originates from the biofilm on the carapace of a shell disease-affected Cancer pagurus specimen, for its potential to produce bioactive secondary metabolites. Its closed genome contains 22 extrachromosomal elements and several gene clusters potentially involved in biosynthesis of bioactive polyketides, bacteriocins, and non-ribosomal peptides. Culture extracts of CP157 showed antagonistic activities against bacteria from different phyla, but also against microalgae and crustacean larvae. Different HPLC-fractions of CP157 culture extracts had antibacterial properties, indicating that several bioactive compounds are produced by CP157. The bioactive extract contains several small, antibacterial compounds that partially withstand elevated temperatures, extreme pH values and exposure to proteolytic enzymes, providing high stability toward environmental conditions in the natural habitat of CP157. Further, screening of 17 Paracoccus spp. revealed that antimicrobial activity, hemolysis and production of N-acyl homoserine lactones are common features within the genus. Taking into account the large habitat diversity and phylogenetic distance of the tested strains, we hypothesize that bioactive secondary metabolites play a central role in the ecology of Paracoccus spp. in their natural environments.

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“…Much research has been devoted to identifying AHLs from marine bacteria, and their effects on microalgae are varied and often subtle. AHLs are frequently isolated from microalgae-associated bacteria, and these bacteria often produce a diverse array of AHLs [23,36,37]. For example, Ziesche et al conducted a chemical survey of marine Roseobacter isolates, identifying a wide variety of AHLs.…”

Section: N-acyl Homoserine Lactonesmentioning

confidence: 99%

How do Quorum Sensing Signals Mediate Algae–Bacteria Interactions?

Dow¹

2021

Preprint

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Quorum sensing (QS) describes a process by which bacteria can sense the local cell density of their own species, thus enabling them to coordinate gene expression and physiological processes on a community-wide scale. Small molecules called autoinducers or QS signals, which act as intraspecies signals, mediate quorum sensing. As our knowledge of QS has progressed, so too has our understanding of the structural diversity of QS signals, along with the diversity of bacteria conducting QS and the range of ecosystems in which QS takes place. It is now also clear that QS signals are more than just intraspecies signals. QS signals mediate interactions between species of prokaryotes, and between prokaryotes and eukaryotes. In recent years, our understanding of QS signals as mediators of algae–bacteria interactions has advanced such that we are beginning to develop a mechanistic understanding of their effects. This review will summarize the recent efforts to understand how different classes of QS signals contribute to the interactions between planktonic microalgae and bacteria in our oceans, primarily N-acyl-homoserine lactones, their degradation products tetramic acids, and 2-alkyl-4-quinolones. In particular, this review will discuss the ways in which QS signals alter microalgae growth and metabolism, namely as direct effectors of photosynthesis, regulators of the cell cycle, and as modulators of other algicidal mechanisms. Furthermore, the contribution of QS signals to nutrient acquisition is discussed, and finally how microalgae can modulate these small molecules to dampen their effects.

show abstract

An Unprecedented Medium-Chain Diunsaturated N-acylhomoserine Lactone from Marine Roseobacter Group Bacteria

Cited by 11 publications

References 37 publications

How Do Quorum-Sensing Signals Mediate Algae–Bacteria Interactions?

How Do Quorum-Sensing Signals Mediate Algae–Bacteria Interactions?

High Potential for Secondary Metabolite Production of Paracoccus marcusii CP157, Isolated From the Crustacean Cancer pagurus

How do Quorum Sensing Signals Mediate Algae–Bacteria Interactions?

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