An unresectable retroperitoneal malignant fibrous histiocytoma: A case report

Abstract

Malignant fibrous histiocytoma (MFH) is most commonly observed in the extremities and the trunk but rarely in retroperitoneum. The present case report documents a 64-year-old man who was admitted with an abdominal palpable mass for 6 months. After a thorough investigation, a tumor of the retroperitoneum was identified adhered to adjacent organs and vessels. The patient experienced mild hydronephrosis and hydroureter as a result of the tumor compression. A number of previous surgeons considered the tumor unresectable and suggested palliative treatment. En bloc resection of the tumor was attempted but incomplete surgery was performed initially as the tumor was friable and prone to bleeding. Therefore, a biopsy of the tumor was performed and a double J ureteral stent was set for hydronephrosis. Histopathological examination confirmed the tumor was an MFH. The patient received neo-adjuvant chemotherapy with 4 cycles of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID). A computed tomography scan demonstrated that the tumor had reduced in size following chemotherapy. En bloc resection of the tumor was arranged again 6 months later. The tumor exhibited a complete response to neo-adjuvant chemotherapy after the formal pathological evaluation. The patient survives without tumor recurrence >5 years without recurrence.

The First Case Treated with Larotrectinib of a Novel TMTC2-NTRK3 Fusion Undifferentiated High-Grade Pleomorphic Sarcoma of the Chest

“…Undifferentiated pleomorphic sarcoma (UPS) was rst described in 1961 by Kauffman as a histiocytic tumor with storiform growth in children [8]. UPS occurs most frequently in patients between 50 and 70 years [9], accounting for 28% of all soft-tissue sarcomas [10]. The major locations of UPS are the lower (49%), upper extremities (19%), while tumors of the abdominal cavity and retroperitoneum account for 16%, and those of the trunk accounts for 9% [11].…”

A rare case of primary malignant fibrous histiocytoma: a sarcoma of the kidney

“…Gil-Julio et al’ reported a case with conservative treatment underwent partial nephrectomy without additional radiotherapy or chemotherapy modalities and survived after 41-month of follow-up period [9]. Cormio et al’ case report showed a conflicting result of a 68 year-old woman whom received adjuvant radiotherapy with considerable long-term survival consequence (72 months after surgery) as well as Hsiao PJ et al ’ whose patient was alive more than 5 five years after neo-adjuvant chemotherapy [37, 38]. On the other hand, Göğüş et al’ report revealed recurrence and metastases after five months postoperatively, and the patient died within the first postoperative year despite of polychemotherapy [26].…”

Retroperitoneal Malignant Fibrous Histiocytoma

“…MFH occurs most commonly in the extremities and the trunk, and it is extremely rare in the retroperitoneum. The tumor is of rare, connective tissue origin with the possibility of occurrence in the retroperitoneal space tumor reached an uncommonly significant size, partly because diagnosis is difficult [1].…”