2023
DOI: 10.1002/bmc.5736
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An untargeted serum and urine lipidomics research based on UPLC–MS revealed the lipid alterations on adjuvant‐induced arthritis rats

Wei Shi,
Yue Han

Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease dominated by chronic inflammatory lesions of peripheral synovial joints. Growing evidence suggests that abnormal lipid metabolism levels contribute to the progression of RA. Although several metabolomics studies have shown abnormality in the RA lipidome, the relationship between the overall lipid metabolites and RA has not been systematically evaluated. In this study, an untargeted lipidomics method based on ultra performance liquid chromatography‐mass… Show more

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