An unusual case of anaemia in an octogenarian

McCusker, L A; Platt, John R.

doi:10.1093/ageing/afs075

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Recently, cure following treatment was reported for an 86-year-old woman diagnosed with VL. 21 Ageing has multiple causes, and genes participating in many important biological pathways can affect ageing rates in animal models. 22 Individuals who reach the age of 80 years and over are likely to have a favourable genetic background that predisposes them to lower risk for disease or at least to a more favourable performance in countering inner homoeostasis imbalances, for instance during infection.…”

Section: Discussionmentioning

confidence: 99%

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

Driemeier

Oliveira

Druzian

et al. 2015

Pathogens and Global Health

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Introduction: Visceral leishmaniasis (VL) is among the seven global endemic diseases assigned a high priority by the World Health Organization. In Latin America, most cases occur in Brazil. Despite the availability of intensive treatment resources and protocols for specific treatment, lethality rates for VL have increased in several regions in the country over the past 10 years, particularly in patients under one and over 50 years of age. As the growth of the elderly population accelerates in Brazil, VL poses a greater challenge to public health. Given the scarcity of studies addressing the disease in this age group, the purpose of this study was to identify factors associated with VL lethality among the elderly. Methods/Key findings: This analytical, cross-sectional epidemiological study comprised 80 elderly patients who sought treatment at the teaching hospital of the Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil, in the period 2000-2013.Clinical, laboratory and treatment variables were investigated from records of elderly patients with VL diagnosis confirmed by at least one laboratory test positive (culture for parasite or direct parasitological examination; reactive immunofluorescence; immunochromatographic test with recombinant antigens) or patients without laboratory confirmation who lived in endemic areas and responded favorably to therapeutic trial, as defined by the Brazilian Ministry of Health. Of the 80 patients included, 78 tested positive to at least one exam; in two cases, diagnosis was based on clinical and epidemiological criteria. The lethality rate was 20%. Multivariate analysis revealed an association between death and time elapsed from symptom onset.

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Section: Discussionmentioning

confidence: 99%

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

Driemeier

Oliveira

Druzian

et al. 2015

Pathogens and Global Health

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“…Outside the European region, cases were diagnosed in Australia (n = 10, [28,36,45,57,64,211,251]), Kenya (n = 16, [16]), Kuwait (n = 36, [19]), Saudi Arabia (n = 35, [259]) and the USA (n = 8, [21,43,49,51,55,60,215]). The predominance of cases from the Mediterranean region likely reflects more intensive travel to southern Europe, especially in people from countries where most cases were diagnosed such as France (n = 107, [6,18,61,68]), the UK (n = 80, [22,38,50,52,58,201,204,207,210,214,219,252,253,261]) and Germany (n = 68, [8,20,25,27,33,35,37,40,44,46,47,53,56,…”

Section: Visceral Leishmaniasismentioning

confidence: 99%

Non-Endemic Leishmaniases Reported Globally in Humans between 2000 and 2021—A Comprehensive Review

Rocha¹,

Pereira

Maia³

2022

Pathogens

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Leishmaniases are human and animal parasitic diseases transmitted by phlebotomine sand flies. Globalization is an important driver of the burden and in the current dynamics of these diseases. A systematic review of articles published between 2000 and 2021 was conducted using the PubMed search engine to identify the epidemiology and clinical management of imported human leishmaniases as a fundamental step to better manage individual cases and traveler and migrant health from a global perspective. A total of 275 articles were selected, representing 10,341 human imported cases. Identified drivers of changing patterns in epidemiology include conflict and war, as well as host factors, such as immunosuppression, natural and iatrogenic. Leishmania species diversity associated with different clinical presentations implies diagnostic and treatment strategies often complex to select and apply, especially in non-endemic settings. Thus, diagnostic and management algorithms for medical clinical decision support are proposed. Increased surveillance of non-endemic cases, whether in vulnerable populations such as refugees/migrants and immunocompromised individuals or travelers, could improve individual health and mitigate the public health risk of introducing Leishmania species into new areas.

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Anämie im Alter

Röhrig

Schulz

2013

Z Gerontol Geriat

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Anemia is not physiologically associated with increasing age but a symptom of an underlying disease. The individual patient's wish, results of geriatric assessment, and therapeutic options regarding life expectancy and quality of life must be taken into consideration when determining the diagnostic steps to be taken. Prevalence of anemia is high, reaching up to 40% among geriatric inpatients. There are various reasons for anemia, but the three most frequent forms of anemia in the elderly are iron deficient anemia (IDA), anemia of chronic diseases (ACD), and unexplained anemia (UA). This article will, therefore, be limited to these forms. Until now no guidelines have been developed concerning diagnostic and therapeutic steps for anemia in the elderly. For basic diagnostics, the analysis of hematologic parameters such as hemoglobin, ferritin, and the saturation of transferrin are recommended. Therapeutic options have to be chosen according to the underlying disease.

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An unusual case of anaemia in an octogenarian

Cited by 4 publications

References 8 publications

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

Non-Endemic Leishmaniases Reported Globally in Humans between 2000 and 2021—A Comprehensive Review

Anämie im Alter

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