An unusual case of basal cell carcinoma of the vulva with lung metastases

Watson, G.M.; Kelly, D. G.; Prior, Lisa; Stanley, Emma; MacEneaney, Owen J.; Walsh, Tom; Kelly, CM

doi:10.1016/j.gore.2016.10.005

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…Other treatment options for superficial spreading tumors include cryosurgery and imiquimod, although tolerance of those treatments in this body area could understandably be poor. Usually, the tumor has a favorable prognosis, however metastatic vulvar BCCs have been reported [9] [10].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of a Large Basal Cell Carcinoma of the Vulva

Stefanaki¹,

Chardalias²,

Fragia³

et al. 2019

OJOG

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We present an interesting and unusual case of a 5 cm well-demarcated erosive plaque on the labia minora, extending to the vagina in an 85-year-old woman, causing pain and discomfort for 2 years. The patient was treated several times with topical and systemic anti-fungals without benefit. Histopathology revealed a typical superficial spreading basal cell carcinoma (BCC) and the patient was referred to a gynecologist for surgical excision. Our case is an alert of BCCs arising on the genital area because they are rare and patients usually present with large lesions, as they do not seek medical attention for what they consider simple irritation. Physicians easily misdiagnose these cancers as inflammatory or infectious dermatoses.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of a Large Basal Cell Carcinoma of the Vulva

Stefanaki¹,

Chardalias²,

Fragia³

et al. 2019

OJOG

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“…Although the death rate from BCCs is low as BCC rarely metastasizes [ 5 , 16 ], if untreated BCC can destroy the tissues and nearby organs, causing ulceration and disfigurement. Advanced BCCs are resistant to treatment and associated with high morbidity [ 1 , 17 , 18 , 19 ]. BCC morbidity is considerable and constitutes a huge burden on the healthcare service worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Those drugs have been particularly directed against smoothened (SMO), which is an important component of the Hh pathway. Although this treatment method has been proven beneficial in many cases [ 23 , 24 ], the development of resistance remains a major concern as about 20% of patients develop resistance during the first year of treatment [ 19 , 23 , 25 ]. Studies have now shown that other pathways interact with the Hh pathway in BCC development [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma

Noubissi

Yedjou

Spiegelman

et al. 2018

IJERPH

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Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs.

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“…Higher frequency of clinical recurrences and regional or distant metastasis (10 out 300 cases described) have been reported for vulvar BCCs. 2-4…”

mentioning

confidence: 99%

“…Higher frequency of clinical recurrences and regional or distant metastasis (10 out 300 cases described) have been reported for vulvar BCCs. [2][3][4] We describe 4 cases of vulvar BCCs, 3 of which were located in the inner side of the labia majora and 1 on the hairy zone of the vulva. In all these cases, we describe also the expression pattern of different cytokeratins and proliferation markers by immunohistochemistry.…”

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confidence: 99%

Vulvar Basal Cell Carcinoma: Four Case Reports With Immunohistochemical Study

et al. 2017

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Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19. Considering that the vulvar region is rich in sebaceous and apocrine units, we hypothesise a glandular origin of BCCs situated in the vulvar region.

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An unusual case of basal cell carcinoma of the vulva with lung metastases

Cited by 9 publications

References 11 publications

A Rare Case of a Large Basal Cell Carcinoma of the Vulva

A Rare Case of a Large Basal Cell Carcinoma of the Vulva

Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma

Vulvar Basal Cell Carcinoma: Four Case Reports With Immunohistochemical Study

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