An unusual case of chronic abdominal pain: an association between Celiac disease and Crohn’s disease

Doya, Leen Jamel; Naamah, Maria; Karkamaz, Noura; Hajo, Narmin; Bijow, Fareeda Wasfy; Ibrahim, Ali; Issa, Rana

doi:10.1093/omcr/omab008

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…In the present study, there were many diseases associated with celiac disease in children and adults; however, in the adult group, Crohn's disease and hypothyroidism seem to be more frequent, as noted in the results of studies by Doya et al (19) and Baharvand et al (20). Rodrigo-Saez et al (16) suggested that most associated diseases in adults are of autoimmune origin.…”

Section: Discussionsupporting

confidence: 63%

Comparative Profile of Celiac Disease Between Children and Adults in Western Algeria Region

El Mehadji,

Noria,

Yekrou

et al. 2023

Zahedan J Res Med Sci

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Background: This study was performed to describe the main differences and similarities of celiac disease according to age and highlight the clinical features, diagnosis, associations of the disease, complications, and response to a gluten-free diet in children and adults. Methods: A retrospective study was conducted on a series of patients (n = 223) diagnosed with celiac disease during infancy (< 2 years) and childhood (≥ 2 years) versus a series of adult patients (≥ 17 years). Results: A total of 223 patients were included in this study, 40, 109, and 74 of whom were infants, children, and adults, respectively. The age of diagnosis was delayed in adults, with a mean value of 21.07 ± 12.49 years versus 03.37 ± 3.93 and 6.53 ± 3.77 years in infants and children, respectively (P < 0.001). The clinical manifestations in infants and children were defined as digestive disorders, mainly chronic diarrhea (P = 0.004), similar in adults. Nevertheless, the extra digestive manifestations were predominant in adults, and anemia was the most frequent manifestation (51.4%) versus 30% (n = 12) and 33.9% (n = 37) in infants and children, respectively (P = 0.026), while weight loss in adults affected 52.7% (P for the difference between the three age groups = 0.004). In adults, there was a higher frequency of associated autoimmune diseases, including hypothyroidism (8.1% versus 4.6% in children), Crohn’s disease (5.4% versus 0.0% in children), and lupus (0.9% versus 0.0% in children) (P < 0.001). Serology was strongly positive in all three age groups but with no significant difference between them (P = 0.184). The difference between the three age groups concerning the immunoglobulin G (IgG) anti-transglutaminase (a-tTG) assay positivity was statistically significant (P < 0.001). The partial grade of villous atrophy was dominant in all three groups. Good adherence to the diet was more noticeable in children than adults (P = 0.001). Conclusions: Celiac disease presents differences between adults and children. The atypical clinical presentation is dominant in adults. Children present a positive serology and good adherence to the diet.

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Section: Discussionsupporting

confidence: 63%

Comparative Profile of Celiac Disease Between Children and Adults in Western Algeria Region

El Mehadji,

Noria,

Yekrou

et al. 2023

Zahedan J Res Med Sci

View full text Add to dashboard Cite

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“…Investigations for IBD in those patients are recommended to prevent advanced manifestations that might include severe malnutrition and edemas like the one we presented here. This also suggests a possible higher rate of undiagnosed IBD-celiac disease patients, especially with the increased risk of IBD in celiac disease patients 11 .…”

Section: Discussionmentioning

confidence: 98%

“…According to previous studies, the co-occurrence of celiac disease and UC is even much rarer. Furthermore, most cases previously reported included either a child over the age of 12 or an adult, and it is unusual to discover such co-occurrence in a child at such an early age as 2 11 .…”

Section: Discussionmentioning

confidence: 99%

Rectal prolapse as a manifestation of inflammatory bowel disease with celiac disease in a 2-year-old male: a rare case report

Martini

Tahhan

Aldarwish

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: The co-occurrence of inflammatory bowel disease (IBD) and celiac disease (CeD) is uncommon. The typical sign of this co-occurrence is malabsorption which leads to anemia, diarrhea, and malnutrition. In rare cases, recurrent rectal prolapse may also occur. Case presentation: A 2-year-old Syrian male baby presented with failure to thrive and chronic diarrhea for 18 months, along with recurrent rectal prolapse for the last 6 months. Biopsies taken confirmed a diagnosis of stage 3b celiac disease according to the Marsh classification. Furthermore, biopsies taken confirmed a diagnosis of IBD. Then, a high-fiber diet to manage IBD and celiac diet were both needed simultaneously, with signs of rectal prolapse, diarrhea, and bloating, occurring when either or both diets were stopped. Clinical discussion: The diagnosis was initially explained by the malnutrition and anemia. Even after the gluten-free diet, the patient showed no improvement in diarrhea and developed inferior gastrointestinal bleeding suggested anal fissure, infectious colitis, polyps, IBD, or solitary rectal ulcer syndrome. The relationship between celiac disease and IBD, in children, is still unclear. Current studies suggest that such co-occurrence is associated with higher risks of developing other autoimmune-related disorders, growth and puberty delay, and comorbidities. Conclusions: In the cases of pediatric co-occurrence of IBD and celiac disease, a conservative therapy consisting of two-fold diets for the two diseases should be tried first. If this step succeeds in controlling the clinical picture, it removes the necessity of introducing immunological pharmacologic treatments that may induce unfavorable side effects in a child.

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An unusual case of chronic abdominal pain: an association between Celiac disease and Crohn’s disease

Cited by 2 publications

References 9 publications

Comparative Profile of Celiac Disease Between Children and Adults in Western Algeria Region

Comparative Profile of Celiac Disease Between Children and Adults in Western Algeria Region

Rectal prolapse as a manifestation of inflammatory bowel disease with celiac disease in a 2-year-old male: a rare case report

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