An unusual case of collagenous gastritis in a middle- aged woman with systemic lupus erythromatosis: a case report

Abstract

IntroductionCollagenous gastritis is a rare histopathologic disease. It is characterized by marked subepithelial collagen deposition with associated inflammatory infiltrate. It is considered an uncommon disease among the general population. Collagenous gastritis without colonic involvement is an extremely rare disease. It is not known to be associated with systemic lupus erythromatosis. This is the first report of this type of association.Case presentationWe present a 47-year-old woman from southeast Asia with dyspepsia and mild anemia. Her past medical history was significant for systemic lupus erythromatosis, autoimmune hemolytic anemia as well as hypothyroidism. Her gastroscopy and colonoscopy results were normal from an endoscopic point of view. However, the histopathology showed collagenous gastritis.ConclusionsTo the best of our knowledge, this is the first case reported of a patient with systemic lupus erythromatosis associated with collagenous gastritis. Further studies are needed to evaluate the association between both diseases from a pathophysiological and immunological perspective.

Collagenous Gastritis in Children: Incidence, Disease Course, and Associations With Autoimmunity and Inflammatory Markers

“…Pediatric cases of CG generally present with severe iron deficiency anemia and/or recurrent abdominal pain ( 22 – 24 , 41 ), whereas diarrhea and malabsorption are the predominant symptoms in adults, presumably linked to the frequently observed concurrent intestinal involvement ( 32 , 46 , 49 ). Associated immune-mediated comorbidities, such as celiac disease and type 1 diabetes, have been reported in both pediatric ( 22 – 24 , 26 , 31 ) and adult ( 3 – 5 , 23 , 24 , 45 , 47 , 50 ) patients. CG is believed to be a chronic disease, and there is currently no effective treatment ( 46 ).…”

Vegetable peptones increase production of type I collagen in human fibroblasts by inducing the RSK-CCAAT/enhancer binding protein-β phosphorylation pathway

“…Therefore, vegetable peptones, with their antiskin aging effects by inducing collagen production and cell proliferation may be useful as an agent for attenuating skin aging. However, overproduction of collagen often induces inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis [48,49]. Therefore, in addition to investigating the efficacy of the vegetable peptones in in vivo models, further studies on the safety of the vegetable peptones are necessary.…”

Collagenous Gastritis: An Unusual Presentation With Tubular Shaped Stomach

“… 1 - 3 Multiple case reports and literature review describe some association between autoimmune diseases and CG, the most common being celiac disease. 4 - 8 …”