An unusual case of congenital scoliosis associated with rib agenesis in the upper part of the concavity treated by VEPTR vertebra to vertebra

Burnei, Gheorghe; Gavriliu, Traian-Stefan; Georgescu, I; Vlad, C; Burnei, Cristian

doi:10.1016/j.spinee.2013.06.086

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Second, the ROR results for the drugs in the combined medications, like ifosfamide, etoposide, everolimus, etc., were much lower when the above method was used to calculate them than the former. The existing literature confirmed that sarcoma usually metastasizes with a stable frequency, most children treated with VEGFR-TKI are already advanced, and lung metastases are more likely (Burnei et al, 2013;Interiano et al, 2015;Murugan et al, 2018;Andión Catalán et al, 2020). Considering the data from FAERS depends on spontaneous reporting, a significant bias would be presented after correlating the presence or not of metastases from sarcoma with the occurrence of pneumothorax.…”

Section: Discussionmentioning

confidence: 99%

Safety profile of vascular endothelial growth factor receptor tyrosine-kinase inhibitors in pediatrics: a pharmacovigilance disproportionality analysis

Xue

Feng

et al. 2023

Front. Pharmacol.

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Introduction: existing research on children consists primarily of phase I/II clinical trials for VEGFR-TKI. System reports of safety on the use of VEGFR-TKI in pediatrics are lacking.Aim: to investigate the safety profiles of VEGFR-TKI in pediatrics via the FDA Adverse Event Reporting System (FAERS).Method: data regarding VEGFR-TKIs were extracted from the FAERS between 2004Q1 to 2022Q3 and categorized by the Medical Dictionary for Regulatory Activities (MedDRA). Population characteristics were analyzed, and reporting odds ratio (ROR) was performed to identify risk signals associated with VEGFR-TKI.Results: 53,921 cases containing 561 children were identified in the database from 18 May 2005, to 30 September 2022. Among those in the system organ class, skin, subcutaneous tissue disorders, and blood and lymphatic system disorders in pediatrics contributed to over 140 cases. Palmar-plantar eythrodysesthesia syndrome (PPES) in VEGFR-TKI presented the most significant 340.9 (95% 229.2–507.0). And pneumothorax also gave a high reporting odds ratio of 48.9 (95% 34.7–68.9). For a specific drug, musculoskeletal pain gave a ROR of 78.5 (95% 24.4–252.6) in cabozantinib and oesophagitis in lenvatinib with a ROR of 95.2 (95% 29.5–306.9). Additionally, hypothyroidism presented a high signal, especially sunitinib, with a ROR of 107.8 (95% 37.6–308.7).Conclusion: the present study explored the safety profile of VEGFR-TKI in pediatrics using the FAERS database. Multiple skin and subcutaneous tissue disorders, as well as blood and lymphatic system disorders, were common VEGFR-TKI-related AEs in system organ class. No serious hepatobiliary AEs were detected. For the specific AEs, PPES and pneumothorax were VEGFR-TKI-related AEs that presented significantly higher signals than those in the general population.

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Section: Discussionmentioning

confidence: 99%

Safety profile of vascular endothelial growth factor receptor tyrosine-kinase inhibitors in pediatrics: a pharmacovigilance disproportionality analysis

Xue

Feng

et al. 2023

Front. Pharmacol.

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“…Depending on segmentation, it may be fully segmented, semi-segmented (partially segmented), or unsegmented. 34 Associated malformations (e.g., heart, spinal cord, kidney) are frequently observed and must be sought on ultrasonography.…”

Section: Imaging Features Of Nonoperative Management Of Scoliosismentioning

confidence: 99%

Scoliosis

Lacroix,

Khalifé,

Ferrero

et al. 2023

Semin Musculoskelet Radiol

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Scoliosis is a three-dimensional spinal deformity that can occur at any age. It may be idiopathic or secondary in children, idiopathic and degenerative in adults. Management of patients with scoliosis is multidisciplinary, involving rheumatologists, radiologists, orthopaedic surgeons, and prosthetists. Imaging plays a central role in diagnosis, including the search for secondary causes, follow-up, and preoperative work-up if surgery is required. Evaluating scoliosis involves obtaining frontal and lateral full-spine radiographs in the standing position, with analysis of coronal and sagittal alignment. For adolescent idiopathic scoliosis, imaging follow-up is often required, accomplished using low-dose stereoradiography such as EOS imaging. For adult degenerative scoliosis, the crucial characteristic is rotatory subluxation, also well detected on radiographs. Magnetic resonance imaging is usually more informative than computed tomography for visualizing associated canal and foraminal stenoses. Radiologists must also have a thorough understanding of postoperative features and complications of scoliosis surgery because aspects can be misleading.

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