An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma

Ustaoğlu, Müge; Koçak, Gülgün; Şiviloğlu, Çiğdem; Cengiz, Ercüment

doi:10.5152/tjg.2018.17288

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…To the best of our knowledge, only 2 cases of small bowel metastasis from PPC have been reported [ 6 , 7 ]. Furthermore, there is only 1 report of duodenal metastasis of PCC, which is a very rare case [ 8 ]. In conclusion, PPC that metastasized to the duodenum is very rare.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report

et al. 2021

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Pulmonary pleomorphic carcinoma (PPC) is a rare subtype of lung sarcomatoid carcinoma that has a poor prognosis, and no standard therapy has been established. Here, we report the case of a 74-year-old man with PCC who showed rare duodenal metastasis. He was referred to our hospital with a mass shadow in the right lung. The patient was diagnosed with PPC clinical stage II B on the basis of immunohistochemical staining from bronchoscopy, and the tumor proportion score of programmed death-ligand 1 was 80%. He did not want any treatment. A year and a half later, progressive anemia was detected. The primary tumor was stable; however, abdominal computed tomography and esophagogastroduodenoscopy revealed a duodenal tumor with stenosis. He was diagnosed with duodenal metastasis from PPC, and he underwent gastrojejunal bypass surgery to prevent bowel obstruction. After surgery, he received pembrolizumab for chemotherapy. However, owing to the progression of peritoneum dissemination, he died 2 months later due to the onset of melena.

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Section: Discussion/conclusionmentioning

confidence: 99%

Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report

et al. 2021

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Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck: A Case Report and Literature Review

Ogawa¹,

Arahata

Kuriyama³

et al. 2021

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We describe our challenge in diagnosing an unusual and rapidly progressing case of pulmonary pleomorphic carcinoma (PPC)—a rare, poorly differentiated, or undifferentiated non-small-cell carcinoma that can metastasize locally or distantly and has a poor prognosis. Our patient was an elderly man with a one-month history of abdominal pain, anorexia, and weight loss, diagnosed with atrophic gastritis via endoscopy, and treated medically without improvement. A week later, this patient developed pain in the head, neck, and shoulder area, and further examination revealed a thickening of his left neck and shoulder, with no palpable lymph nodes. Computed tomography (CT) of the neck, chest, and abdomen led us to believe that we might be dealing with primary sarcoma of the neck since no lung mass was evident. Further investigation could not be performed because the patient’s status deteriorated rapidly. An autopsy revealed that soft tissue in the left neck and the mesentery was invaded by poorly differentiated polymorphic malignant cells, which were also seen in the lung lesion. Immunohistochemically, these malignant cells were all positive for AE1/AE3, CAM5.2, TTF-1, Napsin-A, and Vimentin. The cells were also positive for programmed death-ligand 1 staining with a low level of tumor proportion score (over 1%). The final diagnosis was PPC with metastases to soft tissues in the left neck and the mesentery. A review of previous case reports of PPC revealed that soft tissue is an uncommon site for metastasis, and that our CT findings were rather unusual. We hereby present our case and review of published case reports, with the hope that an awareness of the heterogeneous features of PPC could prompt timely biopsy and histological diagnosis.

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An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma

Cited by 2 publications

References 10 publications

Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report

Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report

Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck: A Case Report and Literature Review

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