An unusual case of elevated liver enzymes (2006: 10b)

O’Brien, Julie; Buckley, Orla; Pl, Munk; Torreggiani, William C.

doi:10.1007/s00330-006-0375-2

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Clinical effects of this vasospasm have been illustrated in case reports causing a diversity of effects such as hemiparesis [ 4 ], optical ataxia and transient cortical blindness [ 5 ] depending on the cerebral vessel affected. The importance of these vasospastic segments is that they serve as a nidus for microangiopathic haemolytic anaemia [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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Second trimester hepatic rupture in a 35 year old nulliparous woman with HELLP syndrome: a case report

et al. 2009

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The HELLP syndrome (haemolysis, elevated liver blood tests and low platelets) is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10-20% of cases with severe preeclampsia. Hepatic capsular rupture is a rare yet dramatic complication of HELLP syndrome. The majority of cases occur in multiparous women over the age of 30. Classically it presents with acute onset right upper quadrant pain in the presence of constitutional symptoms such as vomiting and pyrexia. However, symptoms and signs are usually non specific. Spontaneous hepatic rupture can be preceded by signs of hypovolaemic shock; yet the diagnosis is infrequently made prior to emergent laparotomy. We present the case of a 35 year old nulliparous woman with a second trimester gestational hepatic rupture associated with HELLP syndrome. We briefly discuss the aetiology, diagnostic difficulties and treatment options associated with this rare presentation.

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Section: Discussionmentioning

confidence: 99%

“…Orthotopic liver transplantation should be considered in the setting of uncontrollable haemorrhage, acute liver failure or macroscopic liver necrosis [ 14 ]. Of thirteen documented cases in the literature, ten made a successful recovery [ 6 , 15 ]. The three deaths occurred within 7 weeks of transplantation from prolonged sepsis.…”

Section: Discussionmentioning

confidence: 99%

Second trimester hepatic rupture in a 35 year old nulliparous woman with HELLP syndrome: a case report

et al. 2009

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“…It occurs in 0.17-0.85% of all pregnancies, more frequently in older multiparous Caucasian women (>34 years). Seventy percent of cases are diagnosed antepartum, most frequently between the 27 th and 37 th week of gestation [ 48 ]. The other 30% are diagnosed after delivery.…”

Section: Liver Diseasesmentioning

confidence: 99%

Gastrointestinal diseases during pregnancy: what does the gastroenterologist need to know?

Gomes

Sousa

Lourenço

et al. 2018

aog

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Pregnancy is characterized by numerous physiological changes that may lead to a diversity of symptoms and frequently to gastrointestinal complaints, such as heartburn, nausea and vomiting, or constipation. Chronic gastrointestinal diseases require treatment maintenance during this period, raising the challenging question whether outcomes beneficial to the mother may be harmful for the fetus. In addition, certain diseases, such as acute fatty liver of pregnancy, only develop during pregnancy and may require urgent procedures, such as fetus delivery. Even though they are not present in our day-to-day practice, knowledge of pregnancy-related diseases is fundamental and collaboration between gastroenterologists and obstetricians is often necessary. Herein, we review pregnancy-related diseases and systematize the most appropriate treatment choices according to the recent literature and guidelines, so that the article can serve as a guide to the gastroenterologist regarding the medical approach to pregnancy-related gastrointestinal and liver diseases and their therapeutic management.

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“…The mortality rate among babies born to mothers with HELLP syndrome varies and depends mainly on gestation and birth weight. The common complications of HELLP syndrome include maternal liver haemorrhage or rupture 2 , coagulopathy, postpartum hemorrhage,permanent liver damage or necrosis 3 , which may need transplantation, intraventricular haemorrhage with subsequent hydrocephalus has been reported 4 . Retinal detachment and other eye problems have been reported.…”

Section: Introductionmentioning

confidence: 99%

HELLP Syndrome-A life threatening complication of severe pre eclampsia

Bangal

Chandurkar

Sachdev

et al. 2013

Int J of Biomed & Adv Res

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HELLP Syndrome is a life threatening complication of severe pre eclampsia ,which is characterized by evidence of hemolysis, elevated liver enzymes and low platelet count during second half of pregnancy.If untreated , it carries high risk of maternal and perinatal morbidity and mortality due to hepatic and renal complications. A case of HELLP Syndrome with severe pre eclampsia in a primigravida at 39 weeks of pregnancy is reported. She was a known case of severe pre eclampsia and was taking treatment in a private nursing home.She was refered with a picture of HELLP Syndrome.Caesarean section under general anesthesia for fetal distress was carried out following single donar platelet transfusion. She had gross derrangement of hepatic and renal functions and thrombocytopenia following caesarean section. She was treated aggresively in intensive care unit with transfusion of whole blood ,fresh frozen plasma, multiple single donar platelet transfusions ,antihypertensive agents and broad spectrum antibiotics.Patient required multidisciplinary team approach for management.Patient was discharged after fifteen days from hospital.

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An unusual case of elevated liver enzymes (2006: 10b)

Cited by 6 publications

References 7 publications

Second trimester hepatic rupture in a 35 year old nulliparous woman with HELLP syndrome: a case report

Second trimester hepatic rupture in a 35 year old nulliparous woman with HELLP syndrome: a case report

Gastrointestinal diseases during pregnancy: what does the gastroenterologist need to know?

HELLP Syndrome-A life threatening complication of severe pre eclampsia

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