An unusual case of esophageal adenocarcinoma presenting with disseminated intravascular coagulation (DIC) as a result of carcinomatosis of the bone marrow

Raybould, Alison L.; Rollins‐Raval, Marian A.; McRee, Autumn J.

doi:10.21037/amj.2017.02.12

Cited by 1 publication

(4 citation statements)

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“…Although not listed in PubMed, only one case of esophageal adenocarcinoma with DCBM has been reported 20 . The patient was a 73‐year‐old man with DIC caused by DCBM from a poorly differentiated primary adenocarcinoma of the esophagus.…”

Section: Discussionmentioning

confidence: 99%

“…Disseminated carcinomatosis of the bone marrow is associated with a high rate of DIC, and its prognosis is very poor. Aggressive treatment of malignancy improves DCBM prognosis 20,23 . In DCBM, chemotherapy should be administered promptly before the patient's general condition deteriorates, as rapid deterioration of the patient's general condition may make it difficult to initiate chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Although not listed in PubMed, only one case of esophageal adenocarcinoma with DCBM has been reported. 20 The patient was a 73‐year‐old man with DIC caused by DCBM from a poorly differentiated primary adenocarcinoma of the esophagus. His laboratory data at admission were as follows: Hb, 7.7 g/dL; Plt, 2.0 × 10 4 /μL; albumin, 3.2 g/dL; prothrombin time, 19.5 s; activated partial thromboplastin time, 43 s; international normalized ratio, 1.68; fibrinogen, 130 mg/dL; and d‐Dimer, 2.9 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…Aggressive treatment of malignancy improves DCBM prognosis. 20 , 23 In DCBM, chemotherapy should be administered promptly before the patient's general condition deteriorates, as rapid deterioration of the patient's general condition may make it difficult to initiate chemotherapy. A bone marrow biopsy is commonly performed before initiating treatment for DCBM.…”

Section: Discussionmentioning

confidence: 99%

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An autopsy case of disseminated carcinomatosis of the bone marrow from esophageal adenocarcinoma

Suzuki,

Meguro,

Furusawa

et al. 2023

Clinical Case Reports

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Key Clinical MessageDisseminated carcinomatosis of the bone marrow is rare. We present such a case, which is useful for raising awareness about the importance of early diagnosis and treatment of carcinomas complicated by disseminated carcinomatosis of the bone marrow.AbstractThis is the first autopsy report of disseminated carcinomatosis of the bone marrow (DCBM) in esophageal adenocarcinoma. Advanced poorly differentiated adenocarcinoma with signet ring cell carcinoma arising in Barrett's esophagus caused disseminated intravascular coagulation (DIC) with extensive bone marrow metastasis, resulting in death from cerebral hemorrhage. Although DCBM due to malignancy is rare with poor prognosis, it should be considered in malignancies associated with DIC, and prompt initiation of chemotherapy is the only way to improve the patient's prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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