An Unusual Case of Gastric Cancer Presenting with Breast Metastasis with Pleomorphic Microcalcifications

Luk, Yiu Shiobhon; Ka, Solomon Yig Joon; Lo, Sherwin Shing Wai; Chu, Chi Yeung; Wai, Ming

doi:10.4048/jbc.2012.15.3.356

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…2009 [ 28 ] 65 L Signet-ring cell 24 Right ovarian, liver and lung 6 Soler et al . 2010 [ 9 ] 37 L Signet-ring cell 2 Ovarian 7 [ 29 ] 37 L Signet-ring cell 31 - - [ 30 ] 54 R Signet-ring cell 0 Right ovarian 11 This case 48 R Signet-ring cell 0 Right axillary nodes 2 alive a References are included in [ 18 ]. Interval: the time between the diagnosis of gastric carcinoma and the development of metastasis to the breast; mo, month; Poorly: poorly differentiated adenocarcinoma; Signet-ring cell: signet-ring cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review

Chen

Xia

et al. 2015

World J Surg Onc

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BackgroundCases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been reported in PubMed since 1908.Case presentationWe herein reported a race case of gastric adenocarcinoma with metastasis to the right breast. Breast biopsy showed invasive signet-ring cell breast carcinoma in the right breast. She was given a TEC regimen (docetaxel 75 mg/m2, epirubicin 75 mg/m2, and cyclophosphamide 600 mg/m2 every 3 weeks) for one cycle but showed no objective response. Upper gastrointestinal endoscopy demonstrated an ulcerative mass in the gastric body. Biopsy demonstrated low-grade gastric adenocarcinoma with signet-ring features. In immunohistochemistry, mammary malignant cells were positive for cytokeratin 7, cytokeratin 20, villin, and ErbB2/HER2, but negative for gross cystic disease fluid protein-15, estrogen receptor, and progesterone receptor. The diagnosis of metastatic poorly differentiated signet-ring cell adenocarcinoma of the right breast identical to gastric primary was confirmed finally.ConclusionsGastric cancer with metastasis to the breast can be diagnosed by clinical history, histological findings, and immunohistochemical markers.

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Section: Discussionmentioning

confidence: 99%

Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review

Chen

Xia

et al. 2015

World J Surg Onc

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“…In the literature, cases that associate gastric cancer with muscle metastases are rare, and most of the cases described have a histological profile of SRCC and are associated with advanced disease and poor prognosis. Several other unusual sites of metastasis of gastric cancer have been reported in the literature such as pancreatic, cutaneous, parotid, gingival, mammary, testicular, uterine and fallopian tube metastasis [8,9].…”

Section: Discussionmentioning

confidence: 99%

Muscle Metastases Revealing Gastric Signet Ring Cell Carcinoma: Case Report and Review of the Literature

Mokhlis¹

2019

Austin J Clin Case Rep

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Advanced stomach cancer remains a serious disease with a poor prognosis. Skeletal muscle metastases of gastric carcinoma are extremely rare and may be revealing the disease. The signet ring cell carcinoma is defined by the presence of proportion of independent cells greater than 50%. In an advanced stage it has a more aggressive character with a greater risk of lymph node invasion or distant metastasis. The needle biopsy is required for diagnosis. The chemoresistance of SRCC appear as elements of poor prognosis. The armamentarium includes further the antitumor chemotherapy, radiotherapy and palliative care adapted to the patient's clinical context.

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“…Gastric cancer rarely metasta-sizes to skeletal muscle and most cases of muscle metastasis are associated with advanced disease and poor prognosis. In addition to skeletal muscle, many other unusual sites of metastasis from gastric carcinoma have been reported in the literature – pancreatic, cutaneous, parotid, gingival, breast, testicular, uterine, and fallopian tube metastases [ 7 – 11 ]. Because of their rarity and particular clinical characteristics, these metastases are challenging to diagnose and are frequently part of a widespread metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Metastases as Initial Presentation of Gastric Carcinoma

et al. 2014

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Patient: Male, 67Final Diagnosis: Metastatic gastric carcinomaSymptoms: Painful swelling of soft tissueMedication: Folinic acid • fluouracil • irinotecanClinical Procedure: Radiological-pathological work-upSpecialty: OncologyObjective:Rare diseaseBackground:Gastric carcinoma is one of the most common malignancies in the world. Skeletal muscle metastases from gastric carcinoma are rare.Case Report:We report a case of a 67-year-old man patient with skeletal muscle metastasis developing from gastric carcinoma. He had a painful swelling of the left thigh. A chest computed tomography (CT) scan with enhancement showed pulmonary thromboembolism. Despite heparin therapy, edema and pain of the lower limbs increased bilaterally, so the patient underwent pelvic magnetic resonance imaging (MRI), which documented an altered signal intensity in the upper third of his thighs bilaterally. Furthermore, the examination of the ultrasound (US)-guided biopsy specimen of the left gluteal muscle showed signet ring cell adenocarcinoma metastasis. An upper gastrointestinal tract endoscopy confirmed a gastric ulceration, with a biopsy positive for signet ring cell adenocarcinoma. Because of the advanced stage of disease, the patient underwent only supportive care and died 74 days after admission.Conclusions:Skeletal muscle metastasis may be the initial presentation of gastric carcinoma and diagnosis could be difficult. Biopsy is mandatory for diagnosis.

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An Unusual Case of Gastric Cancer Presenting with Breast Metastasis with Pleomorphic Microcalcifications

Cited by 9 publications

References 11 publications

Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review

Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review

Muscle Metastases Revealing Gastric Signet Ring Cell Carcinoma: Case Report and Review of the Literature

Skeletal Muscle Metastases as Initial Presentation of Gastric Carcinoma

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