An unusual case of Kaposi sarcoma masquerading as cystitis in a kidney transplant recipient

Nair, Vinay; Sheikh, Fatima; Hirschwerk, David; Fahmy, Ahmed; Bhaskaran, Madhu; Grodstein, Elliot; Winnick, Aaron; Maki, Robert G.; Teperman, Lewis; Molmenti, Ernesto P.

doi:10.1111/tid.13132

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Renal involvement of KS in AIDS patients is not commonly observed at imaging; rather, it is more commonly found during autopsy due to its microscopic nature [48]. As with GI KS, associated lymphadenopathy tends to be hypervascular and manifests as enhancing nodes [49]. Differential considerations include Castleman's disease, which can coexist with KS.…”

Section: Genitourinary Kaposi Sarcomamentioning

confidence: 99%

Imaging of Kaposi sarcoma

2021

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Section: Genitourinary Kaposi Sarcomamentioning

confidence: 99%

Imaging of Kaposi sarcoma

2021

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“…Details about the donors, induction therapy, and HHV‐8 testing were generally not reported. Imaging findings were non‐specific and included a focal mass, a thickened renal hilum and sinus, or diffuse heterogeneity on ultrasound, CT or MRI 12,36,39,40 . All of these imaging features have broad overlap between benign and malignant etiologies 36,39,41 .…”

Section: Discussionmentioning

confidence: 99%

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Story

Sanders

Bashir

et al. 2020

Transplant Infectious Dis

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Kaposi sarcoma (KS) following kidney transplantation can result from recipient reactivation of latent human herpesvirus 8 (HHV‐8) infection or activation of donor‐acquired HHV‐8 infection. Post‐transplant KS typically manifests with cutaneous pathology, but rare cases of renal allograft involvement have been reported. We describe two cases of donor‐derived HHV‐8 infection in two hepatitis C (HCV) viremia‐negative transplant recipients who each received a kidney from a donor with HCV viremia. One recipient did not develop KS while the other presented with acute kidney injury caused by extensive KS infiltration of the renal parenchyma and metastatic disease. This report reviews the literature for cases of KS involving the renal allograft and highlights an unexpected consequence of deliberate HCV‐positive organ transplantation.

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“…It typically occurs with dermatologic involvement but recent case reports described cases of disseminated disease without typical skin involvement, which posed an important diagnostic challenge. Atypical localizations included tonsillar Kaposi sarcoma [17], bladder thickening and pelvic lymphadenopathy, penis, lower extremities and thoracic lymph nodes in kidney transplant recipients [18]; liver nodules and portal vein thrombosis in a paediatric liver recipient [12]. Moreover, in 2020, two autopsy-diagnosed cases in renal transplant recipients confirmed that different HHV-8-driven neoplasms could coexist in the same patient: intravascular lymphoma and synchronous Kaposi sarcoma [19].…”

Section: Human Herpesvirus 8-associated Disordersmentioning

confidence: 98%

Human herpesvirus 8 and Kaposi sarcoma: how should we screen and manage the transplant recipient?

Mikulska

Balletto

Mularoni

2021

Current Opinion in Infectious Diseases

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Purpose of review HHV-8-associated diseases are rare but potentially fatal in transplant recipients. Important differences exist in the distribution of HHV-8 seroprevalence, which might contribute to the lack of uniform approach to HHV-8. The aim of this review was to discuss recent updates in screening and management of HHV-8 after transplant. Recent findingsIncreasing attention has been given to the nonmalignant but potentially fatal inflammatory syndrome caused by HHV-8 in solid organ transplant (SOT) recipients. At-risk groups include HHV-8-IgG Dþ/Rtransplant and HHV-8-positive recipients. Severe cases of donor-derived HHV-8 disease, mainly Kaposi sarcoma, frequently without skin involvement and some diagnosed at autopsy, highlight the need to increase clinicians' awareness, to implement effective preemptive strategies and to perform rapid diagnosis. In HSCT setting, HHV-8-associated disorders are very rare.

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An unusual case of Kaposi sarcoma masquerading as cystitis in a kidney transplant recipient

Cited by 8 publications

References 15 publications

Imaging of Kaposi sarcoma

Imaging of Kaposi sarcoma

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Human herpesvirus 8 and Kaposi sarcoma: how should we screen and manage the transplant recipient?

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