An Unusual Case of Lower Extremity Clear Cell Hidradenocarcinoma

Rafols, Marc; Mejia, Odille; Oh, Kei Shing; Bendixen, Blake; Jorge, Irving; Narayanan, Sumana

doi:10.1155/2020/6192109

Cited by 5 publications

(8 citation statements)

References 18 publications

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“…q CONCLUSION L abbaridia et al (20) state that, although HC is a rare eccrine gland tumour, it is nevertheless an aggressive one, and there are no current evidence-based guidelines. However, using sentinel lymph node biopsy, radiotherapy (RT) and chemotherapy (CHT) is still a controversial topic in HC cases (21). As shown by the present report, hidradenoma is a benign tumour, which is nevertheless difficult to differentiate from hidradenocarcinoma.…”

Section: Introductionmentioning

confidence: 83%

Clear Cell Hidradenocarcinoma: a Rare Identity Difficult to Recognize – Case Report and Review of the Literature

Coco

Leanza

Campagnacci

2021

Maedica

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Hidradenocarcinoma (HC) is a malignant and aggressive sweat gland tumour. It is a rare occurrence, accounting for about 6% of malignant eccrine cancers and less than 1% of all cutaneous neoplasms. It is a malignant tumor which can manifest itself in any area of the body, including the anterior surface of the trunk, the torso, scalp, face, and extremities. It is apparent that HC has a high propensity for lymphatic metastasis. The suggested treatment approach for HC implies making a wide surgical excision with negative margins. Nevertheless, such tumours are aggressive and recur locally in 50% of cases; they also produce metastases in 60% of cases. The overall five-year survival rate is 30%. Here, we present the case of a 68-year-old Caucasian male with unknown diagnosis of malignant neoplasm of inguinal cutaneous skin of sweat gland called hydrocarcinoma.

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Section: Introductionmentioning

confidence: 83%

Clear Cell Hidradenocarcinoma: a Rare Identity Difficult to Recognize – Case Report and Review of the Literature

Coco

Leanza

Campagnacci

2021

Maedica

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“…However, approximately 66% of patients present distant extension of the tumor (39% to lymph nodes and 28% to other distant organs that include bone, lung, pleura, skin, and among others), and the local recurrence rate of this type of tumor is high (up to 50%). Therefore, surgical treatment of the tumor is currently combined with regional lymphadenectomy whenever possible if there is regional lymph node involvement, and even prophylactically [ 2 , 3 , 4 , 8 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sentinel node biopsy can be useful in the early diagnosis of lymph node metastases in the subclinical phase in those cases with lesions with data suggesting a high risk of malignancy, such as invasion more than 2 mm in depth, perineural invasion, and histological dedifferentiation [ 2 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Hidradenocarcinoma over a Surgically Excised Hidradenoma of the Foot. A Case Report of a Very Rare Presentation of a Rare Tumor

Saz¹,

Medrano²,

Nielsen³

et al. 2022

JOCR

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Introduction: Hidradenocarcinomas are very rare and aggressive soft-tissue tumors, originated from sweat gland cells, which are located most frequently in head and neck, being their appearance at the extremities rare. This kind of tumor usually appears de novo and very few cases have been reported until now of appearance over benign lesions such as hidradenomas. Malignancy progression rate of hidradenomas is unknown, and this benign lesion has clinical and histopathological characteristics in common with hidradenocarcinomas that could lead to misdiagnosis. Hidradenocarcinomas have a very poor survival rate; therefore, an early diagnosis is essential for a better prognosis, and that is the reason why hidradenomas should be widely excised from the beginning, instead of performing marginal resections of this lesions that could lead to an aggressive recurrence. Case Presentation: Here is a case report of a 27-year-old woman diagnosed with a hidradenocarcinoma over a previously excised hidradenoma in the right foot. The diagnosis was made after right pelvic and inguinal lymphadenopathies appeared few months after a new small asymptomatic lump appeared at the same place in the sole of the right foot were the excised hidradenoma five years before was located. Lymph node biopsy was performed, with histopathological diagnosis of hidradenocarcinoma metastasis. Surgical local wide excision of the lump at the foot and lymphadenectomies was performed. Histopathological analysis of the samples confirmed the diagnosis of hidradenocarcinoma. The patient later received adjuvant radiotherapy and after one year there are no signs of disease recurrence. Conclusion: Many questions remain uncertain about the management and treatment of hidradenocarcinomas due to the rarity of this type of tumor. Although targeted molecular therapies have shown promising results, more studies in this field are necessary. An early diagnosis and differentiation from its benign counterparts that allow local control of the disease before spreading is essential to improve survival rates.

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“…Because it is so rare, the treatment protocols used are a subject of debate. It has local recurrence rates up to 50% and metastasis rates of around 60% despite wide excision, which is the generally accepted treatment method (17,18,19). As dermal lymphatic invasion, nerve sheath involvement, deep structure infiltration, positive resection margins, highly anaplastic morphology, and extracapsular lymph node spread are associated with high recurrence rates, these patients have been recommended adjuvant radiotherapy (20,21).…”

Section: Discussionmentioning

confidence: 99%

A 20-Year Retrospective Analysis of Skin Cancers: Comparison of the First and Second Decades

Derebaşınlıoğlu

Karaca

2020

Konuralp Tıp Dergisi

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The incidence of skin cancer increases day by day depending on environmental factors. Developing diagnostic and pathological methods provide correct typing of skin cancers. Methods: This retrospective analysis included patients who presented to and were scheduled for treatment at Sivas Cumhuriyet University Plastic Reconstructive and Aesthetic Surgery Clinic between January 1, 2000 and December 31, 2019 due to skin cancer and carcinoma in situ. The results were divided two groups as first ten years and second ten years. The groups were compared among themself in terms of cancer type, age, gender and localization. Results: 619 cases of 652 skin cancer and in situ carcinoma results were detected. When the groups were compared in terms of tumor types detected, there was a significant increase in MM, Bowen's disease, and rare NMSC subtypes other than SCC and BCC in the second decade (p<0.001). Comparison of NMSC and MSC rates between the groups showed that the incidence of MSC had increased significantly from 5.2% to 10% in the past 10 years (p<0,05). Conclusions: Rare Non-melanocytic skin cancer group includes many types of carcinoma, there are various treatment protocols. Furthermore, many members of this group are known to be more aggressive than Basal cell carcinoma and squamous cell carcinoma. There are no consensus especially for approaches targeting lymph nodes. Closely following is necessary for early detection of recurrences and metastases.

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An Unusual Case of Lower Extremity Clear Cell Hidradenocarcinoma

Cited by 5 publications

References 18 publications

Clear Cell Hidradenocarcinoma: a Rare Identity Difficult to Recognize – Case Report and Review of the Literature

Clear Cell Hidradenocarcinoma: a Rare Identity Difficult to Recognize – Case Report and Review of the Literature

Hidradenocarcinoma over a Surgically Excised Hidradenoma of the Foot. A Case Report of a Very Rare Presentation of a Rare Tumor

A 20-Year Retrospective Analysis of Skin Cancers: Comparison of the First and Second Decades

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