An unusual case of neuroma of the median nerve.

Kanagasuntheram, R.; Wong, Weng-Fai

doi:10.1136/jnnp.32.5.428

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…There are some articles about post-taumatic or non-traumatic median nerve masses in the literature. In 1969, Kanagasuntheram and Wong [ 4 ] reported post-taumatic neuroma. A two cm sized neuroma occured after distal radius fracture and trapped in fracture line was disgussed.…”

Section: Discussionmentioning

confidence: 99%

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Post-traumatic Median Nerve Neuroma in Wrist. A Case Report and brief review of Literature

Aslan¹,

Konya²,

Sargın³

2013

J Ortho Case Reports

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Introduction:Distal median nerve masses may be developed post-traumatic or non-traumatic. In this paper, we aim to present a 52 year old female case with a postraumatic neuroma of the median nerve in the left wrist.Case Series:A 52-year-old female patient had accidental incised wound over her left wrist which was primarily sutured. She presented 6 months later with unrelieved pain and growing swelling at the wrist. USG showed solid mass of size 2x3 cms. Intraoperatively the mass was seen to arise from medial nerve and careful excision was done protecting the nerve. At one year follow up the patient is relived of her symptoms with no sensorimotor deficit.Conclusion:Post traumatic neuroma present as unrelieved pain and progressive swelling. A high index of suspicion should be kept in cases of wound that are primarily sutured over an area with superficial nerves. Careful excision of the lesion is very effective in relieving patients symptoms

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Section: Discussionmentioning

confidence: 99%

“…Neuromas are the most common solid peripheral nerve tumor frequently seen in 30-60 ages [13]. Neuromas can originate after trauma to the nerves and such cases are rarely reported in literature [ 4 - 6 ].…”

Section: Introductionmentioning

confidence: 99%

Post-traumatic Median Nerve Neuroma in Wrist. A Case Report and brief review of Literature

Aslan¹,

Konya²,

Sargın³

2013

J Ortho Case Reports

View full text Add to dashboard Cite

show abstract

“…We also attempted to visualize the nonpeptidergic subclass of nociceptors in the skin, 36 using a histochemical staining method (i.e., acetylcholinesterase) 44 and various immunohistochemical markers (i.e., P2X 3 , IB4, RET, GINIP), 36 , 45 – 47 at varying concentrations and using specific protocols but were unable to obtain reproducible staining patterns allowing for quantification of these fibers.…”

Section: Methodsmentioning

confidence: 99%

Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain

et al. 2018

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Bortezomib is a mainstay of therapy for multiple myeloma, frequently complicated by painful neuropathy. The objective of this study was to describe clinical, electrophysiological, and pathological changes of bortezomib-induced peripheral neuropathy (BiPN) in detail and to correlate pathological changes with pain descriptors. Clinical data, nerve conduction studies, and lower leg skin biopsies were collected from 22 BiPN patients. Skin sections were immunostained using anti-protein gene product 9.5 (PGP9.5) and calcitonin gene-related peptide (CGRP) antibodies. Cumulative bortezomib dose and clinical assessment scales indicated light-moderate sensory neuropathy. Pain intensity >4 (numerical rating scale) was present in 77% of the patients. Median pain intensity and overall McGill Pain Questionnaire (MPQ) sum scores indicated moderate to severe neuropathic pain. Sural nerve sensory nerve action potentials were abnormal in 86%, while intraepidermal nerve fiber densities of PGP9.5 and CGRP were not significantly different from healthy controls. However, subepidermal nerve fiber density (SENFD) of PGP9.5 was significantly decreased and the axonal swelling ratio, a predictor of neuropathy, and upper dermis nerve fiber density (UDNFD) of PGP9.5, presumably representing sprouting of parasympathetic fibers, were significantly increased in BiPN patients. Finally, significant correlations between UDNFD of PGP9.5 versus the evaluative Pain Rating Index (PRI) and number of words count (NWC) of the MPQ, and significant inverse correlations between SENFD/UDNFD of CGRP versus the sensory-discriminative MPQ PRI/NWC were found. BiPN is a sensory neuropathy, in which neuropathic pain is the most striking clinical finding. Bortezomib-induced neuropathic pain may be driven by sprouting of parasympathetic fibers in the upper dermis and impaired regeneration of CGRP fibers in the subepidermal layer.

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An unusual case of neuroma of the median nerve.

Cited by 2 publications

References 10 publications

Post-traumatic Median Nerve Neuroma in Wrist. A Case Report and brief review of Literature

Post-traumatic Median Nerve Neuroma in Wrist. A Case Report and brief review of Literature

Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain

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