An Unusual Case of Paraganglioma of the Broad Ligament Presenting as Cystic Mass

Khandeparkar, Siddhi Gaurish Sinai; Kulkarni, M. L.; Gaopande, Vandana L.; Joshi, Avinash R; Naphade, Pushpalata

doi:10.1155/2016/1041989

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…The following parameters may be taken into account for malignant potential and behaviour of paragangliomas: location, size, Pheochromocytoma of Adrenal Gland Scales Score(PASS) ,S-100 immunoreactivity and Ki-67 labelling index. [6] In the present case, the tumor cells were positive for synaptophysin and chromogranin indicating that it was a neuroendocrine tumor. Pancytokeratin and EMA were negative, indicating nonepithelial tumor.…”

Section: Case Historysupporting

confidence: 47%

Mesenteric Paraganglioma-A Cyst in The Mist

Saniha

Jadhav

Kittur

2020

Ann of Pathol and Lab Med

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Extraadrenal paraganglioma is rarely found in the mesentery. It accounts only for 5-10% of cases and may present incidentally as abdominal mass. We report a case of 30 year old male presented as mass per abdomen. A differential diagnosis of neurogenic tumor or cystic mesothelioma was considered based on CT-abdomen. Histopathological examination showed features of mesenteric paraganglioma and confirmed on immunohistochemistry. This case report highlighted several important key issues regarding diagnosis of paraganglioma, including malignant or metastatic potential, recurrence rate, pre and postoperative imaging study and lifelong follow-up of the patient.

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Section: Case Historysupporting

confidence: 47%

Mesenteric Paraganglioma-A Cyst in The Mist

Saniha

Jadhav

Kittur

2020

Ann of Pathol and Lab Med

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“…Paragangliomas of the female genital tract are also extremely rare. In a review of the literature, the vagina is the most common site, with occasional cases also reported in the vulva, ovary, broad ligament, and uterine corpus 3–16. To date, as far as we are aware, no cases arising in the uterine cervix have been reported.…”

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confidence: 99%

Cervical Small Cell Variant of Paraganglioma With Sarcomatous Transformation: Report of a Unique Case

Razack

Butt

Coetzee

et al. 2021

International Journal of Gynecological Pathology

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We report a unique primary cervical neoplasm in a 44-yr-old woman which we believe, based on the morphology and immunophenotype, represents an extremely unusual small cell variant of paraganglioma. This represents the first report of a primary cervical paraganglioma. Following chemoradiation treatment, the tumor underwent malignant transformation into an S100 and SOX10 positive sarcoma, morphologically and immunohistochemically resembling a malignant peripheral nerve sheath tumor, which we believe represents a sarcoma derived from the sustentacular cells of the paraganglioma. Mutational analysis detected a nonsense mutation of NF1 gene in the sarcoma. This further supports the diagnosis as both somatic and germline NF1 mutations have been associated with paragangliomas and malignant peripheral nerve sheath tumors. Targeted RNA sequencing (ARCHER, expanded sarcoma panel) covering many known genes implicated in sarcoma development, did not reveal any other molecular alteration (fusion or internal tandem duplication).

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An Unusual Case of Paraganglioma of the Broad Ligament Presenting as Cystic Mass

Cited by 2 publications

References 14 publications

Mesenteric Paraganglioma-A Cyst in The Mist

Mesenteric Paraganglioma-A Cyst in The Mist

Cervical Small Cell Variant of Paraganglioma With Sarcomatous Transformation: Report of a Unique Case

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