“…[2][3][4] In the remaining two cases, pregnancy and labor were associated with the rupture without any other causes. 5,6 The identified causes of acute mitral regurgitation due to rupture of chordae tendineae are primary, spontaneous, and secondary. Possible causes include IE, congenital, rheumatic, or ischemic heart disease, Marfan syndrome, osteogenesis imperfect, connective tissue diseases, hypertrophic obstructive cardiomyopathy, Ehlers-Danlos syndrome, previous mitral valve surgery, blunt trauma, and pregnancy.…”