An unusual case of prolonged tinnitus following low-dose amitriptyline

Mendis, Dulani; Johnston, M. N.

doi:10.1177/0269881107082126

Cited by 13 publications

(11 citation statements)

References 6 publications

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“…Trimipramine was evaluated in a small double blind, placebo crossover study (68), which did not demonstrate a difference between trimipramine and placebo treatment. Interestingly, tricyclic antidepressants have also been repeatedly found to induce tinnitus (69–71). Serotonin reuptake inhibitors have also been investigated for the treatment of tinnitus.…”

Section: Existing Treatmentsmentioning

confidence: 99%

Emerging pharmacotherapy of tinnitus

Langguth

Salvi²,

Elgoyhen

2009

Expert Opinion on Emerging Drugs

116

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Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about one in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life. Since tinnitus is frequently associated with irritability, agitation, stress, insomnia, anxiety and depression, the social and economic burdens of tinnitus can be enormous. No curative treatments are available. However, tinnitus symptoms can be alleviated to some extent. The most widespread management therapies consist of auditory stimulation and cognitive behavioural treatment, aiming at improving habituation and coping strategies. Available clinical trials vary in methodological rigor and have been performed for a considerable number of different drugs. None of the investigated drugs have demonstrated to provide replicable long-term reduction of tinnitus impact in the majority of patients, in excess of placebo effects. Accordingly, there are no FDA- or EMEA-approved drugs for the treatment of tinnitus. However, in spite of the lack of evidence, a large variety of different compounds are prescribed off-label. Therefore, more effective pharmacotherapies for this huge and still growing market are desperately needed and even a drug that produces only a small but significant effect would have an enormous therapeutic impact. This review describes current and emerging pharmacotherapies with its current difficulties and limitations. In addition, it provides an estimate of the tinnitus market. Finally, it describes recent advances in the tinnitus field which may help overcome obstacles faced in the pharmacological treatment of tinnitus. These include incomplete knowledge of tinnitus pathophysiology, lack of well established animal models, heterogeneity of different forms of tinnitus, difficulties in tinnitus assessment and outcome measurement and variablility in clinical trial methodology.

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Section: Existing Treatmentsmentioning

confidence: 99%

Emerging pharmacotherapy of tinnitus

Langguth

Salvi²,

Elgoyhen

2009

Expert Opinion on Emerging Drugs

116

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“…Some of these reports describe that tinnitus subsided when antidepressants stopped whereas others not. Most of reports in females like our patient and most of them use tricyclic antidepressants (imipramine and amitripty line) in average dose for patients with depression [1][2].Tinnitus in these reports occurs within 2 weeks of using amitripty line or imipramineat average daily dose of (50-150 mg) per day. Tinnitus in these reports resolved within 1 week.…”

Section: Discussionmentioning

confidence: 68%

“…By searching PubMed and Cochrane Database, few previous reports were found about antidepressants induced tinnitus. There are five reported cases of tinnitus following using of tricyclic antidepressants [1,2,10,12,13] and two reported cases with venlafaxine [9,11]. In this report, the case of patient who experience tinnitus following using of citalopram.…”

Section: Introductionmentioning

confidence: 86%

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Tinnitus following Antidepressant use in a Female with Depression

Almatham¹

2014

J Psychiatry

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This case report describes 37-year-old female known case of Major Depression (DSM-IV-TR) for 12 years. She develops tinnitus 3 weeks after starting citalopram 40 mg daily and psychotherapy sessions, which resolved completely when citalopram discontinued. She was distressed by that sound scoring 40 on Tinnitus Handicapped Inventory Severity Scale (THI). ENT referral excludes other medical possibilities of Tinnitus. It is rare side effect of antidepressant specially SSRIs. In fact there are few trials of antidepressants has been used to treat tinnitus. With this report literature review about antidepressants induced tinnitus is provided.

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“…A possible dose effect may exist as lower doses have sometimes been related to tinnitus onset,58,59 even when the same agents were reported as being effective60 (as in non-TCA heterocyclic antidepressants such as trazodone61 and mianserin) 62…”

Section: Psychopharmacological Treatmentmentioning

confidence: 99%

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

Fornaro

Martino

2010

NDT

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Background:Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience.Method:A comprehensive review of MEDLINE literature (from January 1990–January 2010) was performed searching for: “tinnitus”, major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents.Results:Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies.Conclusions:Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions at the cochlea.

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An unusual case of prolonged tinnitus following low-dose amitriptyline

Cited by 13 publications

References 6 publications

Emerging pharmacotherapy of tinnitus

Emerging pharmacotherapy of tinnitus

Tinnitus following Antidepressant use in a Female with Depression

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

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