An Unusual Case Report Of Hepatocellular Carcinoma Metastasis To The Chest Wall Presenting As Breast Lump

Ahmad, Kaleem; Sah, Pankaj; Dhungel, K; Gupta, Mrinal; Rauniyar, RK; Ansari, Sajid Ali; Paudyal, Poonam

doi:10.3126/njms.v1i2.6616

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…1 Metastases to the chest wall is an unusual occurrence. 5 A study of 342 patients of HCC with extrahepatic metastasis conducted by Uchino et al found only 8.18% patients to have extrahepatic metastasis on initial presentation. 1 The described case presented solely with an isolated chest wall swelling, diagnosed on FNAC.…”

Section: Discussionmentioning

confidence: 99%

“…Most common sites of metastasis are lungs, regional lymph nodes, bone, adrenal gland, pancreas, kidney and peritoneum while unusual sites are skeletal muscle and skin 1 . Metastases to the chest wall is an unusual occurrence 5 . A study of 342 patients of HCC with extrahepatic metastasis conducted by Uchino et al found only 8.18% patients to have extrahepatic metastasis on initial presentation 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to the chest wall has been reported rarely. Although, 15%–17% patients have metastases at the time of diagnosis, presentation with symptoms exclusively related to metastases is rare 5 …”

Section: Introductionmentioning

confidence: 99%

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Hepatocellular carcinoma presenting as a chest wall mass – An unusual case diagnosed on cytology with review of literature

Agnihotri

Sathe

Singh

et al. 2023

Diagnostic Cytopathology

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Hepatocellular carcinoma (HCC) is associated with an aggressive behavior and a strong tendency for extrahepatic metastasis. Although 5%–15% patients have metastases at diagnosis, presentation with symptoms exclusively related to extrahepatic metastases is rare. An 82‐year‐old male presented with an isolated left anterolateral chest wall swelling. Ultrasonography revealed a soft tissue mass involving the anterior chest wall with adjacent rib erosion. Serum protein electrophoresis showed increase in beta‐2 region. A clinical diagnosis of multiple myeloma was considered. Fine needle aspiration cytology from the swelling showed loosely cohesive clusters of polygonal cells with traversing blood vessels. Cells showed abundant vacuolated to granular cytoplasm, round nuclei with frequent intranuclear cytoplasmic inclusions. A differential of metastatic HCC and renal cell carcinoma was considered. Subsequent imaging showed a 12 cm mass in the liver. Biopsy from chest wall mass with immunohistochemistry confirmed the diagnosis. Lungs and lymph nodes are the commonest sites for metastatic HCC; presentation as chest wall metastasis is rarely reported. The classical cytomorphology of HCC proved useful in diagnosing metastasis at a rare site. Recent studies have shown that beta‐2‐globulin is a promising biomarker for early diagnosis of HCC in patients with chronic liver disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatocellular carcinoma presenting as a chest wall mass – An unusual case diagnosed on cytology with review of literature

Agnihotri

Sathe

Singh

et al. 2023

Diagnostic Cytopathology

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“…Although the metastatic sites were various, cases with metastatic HCC with no primary sites are occasionally reported. [7][8][9][10][11] Spontaneous tumor regression is rare, but with higher incidence of HCC compared to other cancers. 12 Two meta-analyses on spontaneous regression of primary HCC have been reported, however the mechanism of this phenomenon has not yet been identified.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

Hwang

Lee

et al. 2015

Korean J Gastroenterol

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The occurrence of hepatocellular carcinoma (HCC) is closely associated with viral hepatitis or alcoholic hepatitis. Although active surveillance is ongoing in Korea, advanced or metastatic HCC is found at initial presentation in many patients. Metastatic HCC presents with a hypervascular intrahepatic tumor and extrahepatic lesions such as lung or lymph node metastases. Cases of HCC presenting as carcinoma of unknown primary have been rarely reported. The authors experienced a case of metastatic HCC in a patient who presented with a metastatic bone lesion but no primary intrahepatic tumor. This case suggests that HCC should be considered as a differential diagnosis when evaluating the primary origin of metastatic carcinoma. (Korean J Gastroenterol 2015;66:50-54)

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An Unusual Case Report Of Hepatocellular Carcinoma Metastasis To The Chest Wall Presenting As Breast Lump

Cited by 2 publications

References 13 publications

Hepatocellular carcinoma presenting as a chest wall mass – An unusual case diagnosed on cytology with review of literature

Hepatocellular carcinoma presenting as a chest wall mass – An unusual case diagnosed on cytology with review of literature

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

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