An Unusual Cause of Limping in a 2-Year-Old Girl: Synovial Chondromatosis of the Knee

Pirimoğlu, Berhan; Koru, Ahmet Taha; Yalçın, Ahmet; Polat, Gökhan; Sade, Recep

doi:10.1097/phm.0000000000001494

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…2020 [ 26 ] 10 F Left patella Pain and deformity of left patella precipitated by trauma for 6 months Plain radiographCT scanMRI Cartilaginous metaplastic, uniform chondrocytes with moderate pleomorphism without cellular atypicality Arthrotomy with loose body removal Pirimoglu B. 2021 [ 14 ] 2 F Right knee Pain for over 1 month Plain radiographUltrasoundMRI N/A Open surgical excision with synovectomy and removal of loose bodies Our patient 12 F Right knee Pain with inability to bear weight for 2 months Plain radiograph MRI Osteocartilagenous nodules covered by synovial tissue, clusters of chondrocytes arranged in lobules, chondrocytes with mild nuclear atypia, intense calcification and ossification; no pannus, no lymphoid follicles, no acute inflammation, no tumor or granulomatous inflammation Unresponsive to initial treatment (NSAIDs, methotrexate, and sulfasalazine) for presumed JIA. Subsequent arthroscopic removal of loose bodies and partial synovectomy with synovial biopsy.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Synovial osteochondromatosis mimicking juvenile idiopathic arthritis in an adolescent: a case-based review

et al. 2022

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Synovial osteochondromatosis is an extremely rare benign condition in children and adolescents that have joint pain as a presenting manifestation. It is usually monoarticular with the knee as the most common affected joint. In this article, we describe the case of a female adolescent suffering from debilitating chronic right knee pain initially mimicking juvenile idiopathic arthritis, who was subsequently diagnosed with primary synovial osteochondromatosis. We present a review of synovial osteochondromatosis focusing on the clinical manifestations, radiographic features, histopathologic findings, and treatment, with a summarized review of pediatric patients with initial musculoskeletal presentations who were ultimately diagnosed as synovial osteochondromatosis. Although synovial osteochondromatosis is rare in children and adolescents, this condition should be included in the differential diagnosis of joint pain and may mimic juvenile idiopathic arthritis. Appropriate diagnostic radiography, including both plain radiography and magnetic resonance imaging, is necessary to accurately diagnose this condition. We also emphasize the importance of a multidisciplinary team approach to managing patients with synovial osteochondromatosis.

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Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Synovial osteochondromatosis mimicking juvenile idiopathic arthritis in an adolescent: a case-based review

et al. 2022

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Primäre synoviale Chondromatose

Riechelmann

Hackl

Schmitz³

et al. 2022

Arthroskopie

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Zusammenfassung Hintergrund Die primäre synoviale Chondromatose (SC) ist eine seltene Erkrankung der Synovialmembran unklarer Ätiologie. Der aktuelle Wissensstand zu dieser Erkrankung soll in einer kurzen Übersicht dargestellt werden. Methoden Übersichtsarbeiten und rezente Fallberichte zur SC wurden systematisch ausgewertet und mit Daten eigener Fälle in Kontext gesetzt. Ergebnisse Auf Grund neuer genomischer Daten wird die SC als benigne Neoplasie eingestuft. In 60 % der Fälle liegen Mutationen im Fibronektin-1-Gen (FN1) und/oder im Gen für den Activin-A-Typ-II-Rezeptor (ACVR2A) vor. Diagnoseweisend ist die Magnetresonanztomographie (MRT) und die meist arthroskopische Biopsie der Synovia. An einem Fallbeispiel soll gezeigt werden, dass die Knorpelaggregate der SC radiologisch nicht immer schattengebend sein müssen. Differenzialdiagnostisch kommen Monarthritiden anderer Ursachen, andere Gelenk- und Muskelerkrankungen mit Mineralisierung sowie weitere von der Synovialmembran ausgehende Erkrankungen in Betracht. Die Entartungsrate liegt bei 2–4 %. Therapeutisch hat sich in den letzten Jahren das arthroskopische Vorgehen durchgesetzt, das an die Ausdehnung der Erkrankung adaptiert wird. Schlussfolgerung Genomische Untersuchungen sowie Fallserien und Fallberichte aus jüngerer Zeit werfen ein neues Licht auf die SC. Therapeutisch wird in jüngeren Arbeiten überwiegend arthroskopisch vorgegangen.

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Primary articular synovial chondromatosis of the fifth metacarpophalangeal joint in a child

Dejonghe

Cromheecke

Keyzer

et al. 2023

Hand Surgery and Rehabilitation

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An Unusual Cause of Limping in a 2-Year-Old Girl: Synovial Chondromatosis of the Knee

Cited by 3 publications

References 3 publications

Synovial osteochondromatosis mimicking juvenile idiopathic arthritis in an adolescent: a case-based review

Synovial osteochondromatosis mimicking juvenile idiopathic arthritis in an adolescent: a case-based review

Primäre synoviale Chondromatose

Primary articular synovial chondromatosis of the fifth metacarpophalangeal joint in a child

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