An unusual cause of pleural effusion

Youngster, Ilan; Vaisben, Eleonora; Cohen, Hector; Nassar, Faris

doi:10.1093/ageing/afj009

Cited by 17 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After excluding reports of HHV8-associated PEL and cases of T-cell or null immunophenotype, we identified 34 articles describing 46 unique cases [4–37]. Our review includes these 46 cases and our 2 cases for a total of 48 reported cases of HHV8-negative PEL.…”

Section: Resultsmentioning

confidence: 99%

“…Our findings suggest that chemotherapy benefits most patients, as those treated with any type of chemotherapy overall had a lower rate of death compared to patients who received no chemotherapy. Remarkably, the addition of rituximab to chemotherapy regimens induced remission in all 8 patients, 7 of whom were alive at the time of last follow-up [4, 8, 12, 13, 29, 31, 32]. The single patient who died following a rituximab-containing regimen died prematurely of a cause unrelated to lymphoma [8].…”

Section: Discussionmentioning

confidence: 99%

“…ISH for EBV-encoded RNA (EBER) was negative. Immunoglobulin heavy chain ( IGH@ ) gene rearrangement studies showed a clonal pattern [4]. F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT whole body scan for staging did not demonstrate additional sites of disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

Saini

Hochberg

Linden

et al. 2013

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

Saini

Hochberg

Linden

et al. 2013

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

show abstract

“…However, this entity has been reported in a small number of cases associated with HHV8‐unrelated PEL‐like lymphoma. In the literature, we found 30 HHV8‐unrelated PEL‐like lymphoma HIV‐negative cases (4–27). Here, we present a rare case of PEL in an elderly patient without HIV or HHV‐8 infection who was followed up without therapy for 40 months.…”

mentioning

confidence: 99%

Human herpes virus 8‐unrelated primary effusion lymphoma‐like lymphoma: report of a rare case and review of the literature

Adiguzel¹,

Bozkurt

Kaygusuz³

et al. 2009

APMIS

View full text Add to dashboard Cite

A rare case of human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma: a report and review of the literature. APMIS 2009; 117:222-29. Primary effusion lymphoma (PEL) is a very rare type of lymphoma usually confined to the body cavities predominantly in immunosuppressed patients infected with human herpes virus 8 (HHV-8). The new term for HHV-8 independent PEL is HHV8-unrelated PEL-like lymphoma. We describe an 89-year-old human immunodeficiency virus (HIV)-negative male patient with HHV8-unrelated PEL-like lymphoma in the pleura. No hepatosplenomegaly or lymphadenopathy was detected. Chest radiography and computed tomography revealed right pleural effusion, but no evidence of tumor mass or lymph node enlargement. Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for CD45, CD30, CD38, CD7 and CD71. Because of the advanced age, no chemotherapy was given. Effusion resolved spontaneously. One year after the diagnosis, a new pleural effusion developed at the left side. Following thoracentesis and pleurodesis, the patient remained in complete remission for 40 months. To date, 30 cases of HHV8-unrelated PEL-like lymphoma/HIV negative have been reported in the literature. The outcome of the HHV8-unrelated PEL-like lymphoma patients who were HIV negative seems to be better than HIV- and HHV-8-positive PEL.

show abstract

“…[ 50 ] In extremely rare cases, it can also exist in the absence of HIV and HHV-8. [ 51 ] PEL usually arises in body cavities, such as the pleural space or the pericardium, hence also “body cavity lymphoma.”…”

Section: Primary Effusion Lymphomamentioning

confidence: 99%

Primary pulmonary lymphoproliferative neoplasms

et al. 2018

View full text Add to dashboard Cite

Pulmonary lymphoproliferative neoplasms are rare lung tumors and account for <1% of all lung tumors. Among them, primary pulmonary lymphomas (PPL) constitute the majority, which include Non-Hodgkin’s lymphoma (NHL) that comprise of mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphomas and other rare types of NHL and lymphomatoid granulomatosis. HL, which arises secondary to contiguous spread from the mediastinum, is the rarest type of PPL. Other entities described within the umbrella of pulmonary lymphoproliferative neoplasms include pleural lymphomas and posttransplant lymphoproliferative disorders (PTLD) – which occurs in the poststem cell and organ transplant patients. These neoplasms although rare, have a favorable prognosis, which does not depend on disease resectability. Moreover, with its nonspecific presentation, diagnosis is challenging, which often leads to delayed diagnosis or misdiagnosis in many cases. Therefore, knowledge of this entity is important for the practicing pulmonologist. This review article aims to describe the clinical presentation, diagnosis and management of primarily the entities within PPL, as well as pleural lymphomas and PTLD.

show abstract

An unusual cause of pleural effusion

Cited by 17 publications

References 6 publications

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

Human herpes virus 8‐unrelated primary effusion lymphoma‐like lymphoma: report of a rare case and review of the literature

Primary pulmonary lymphoproliferative neoplasms

Contact Info

Product

Resources

About