An Unusual Cause of Postpolypectomy Bleeding

Kaila, Vishal; Desai, Amit A.

doi:10.1053/j.gastro.2020.02.063

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…Cases in the small intestine, references: ( 16 , 17 , 23 , 24 , 29 – 32 , 40 , 52 – 76 ). Cases in the colon, references: ( 26 , 77 – 79 ). Cases in the appendix, references: ( 33 , 39 , 65 , 80 ).…”

Section: Figurementioning

confidence: 99%

Gastrointestinal Myeloid Sarcoma a Case Presentation and Critical Review of the Literature

Kheirkhah

Avila-Rodriguez

Radzik

et al. 2021

Mediterr J Hematol Infect Dis

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Myeloid sarcomas can be detected in up to 30% of acute myeloid leukemia cases or occur de-novo without bone marrow involvement. The most frequent localization of myeloid sarcomas in the abdominal cavity is the small intestine, and gastric presentations are infrequent, frequently misdiagnosed, and a high level of suspicion should exist when the characteristic histomorphology features are present. The current review features a case report with gastric presentation of myeloid sarcoma in a patient with a diagnosis of acute myeloid leukemia with trisomy 8. In addition, a review of the literature of intestinal type myeloid sarcomas shows that less than 15% of these cases have been reported in the stomach. The most common molecular aberrancy detected in intestinal myeloid sarcomas is the fusion protein CBFB-MYH11. Review of several large studies demonstrates that the presence of myeloid sarcoma does not constitute an independent prognostic factor. The therapeutic approach will be tailored to the specific genetic abnormalities present, and systemic chemotherapy with hematopoietic stem cell transplant are the most efficient strategies.

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