An Unusual Cause of Spontaneous Paralysis

Birmingham, Colleen; Tibbles, Carrie; Friedberg, Ryan

doi:10.1016/j.jemermed.2009.02.011

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…To analyze the outcome, the patients' neurological status at admission versus followup/discharge (f/u) was quantified and compared using the mMcCS (Table 1). For one patient (ID#9), no outcome was reported [7]. Regarding the post-therapeutic recovery, two patients (ID#6 and ID#11) improved by one point and another two patients (ID#8 & ID#10) by two points in mMcCS.…”

Section: Systematic Review Of the Literaturementioning

confidence: 96%

“…A total of 11 patients who suffered from acute, severe SEL could be identified through the systematic review of the literature [6,7,[14][15][16][17][18][19][20][21][22]. In addition, there was a prospectively recorded case from our clinic (Supplementary Text and Figure S2), giving a total of 12 patients for analysis (Table 1).…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…Furthermore, there is even less knowledge available on how to treat the acute SEL cases [6]. When faced with rapidly progressing neurological decline, physicians are thereby left with little choice but to offer maximum therapy (i.e., surgery) [7]. With the current study, we analyzed all published patients suffering from acute, severe SEL and additionally presented the experience gained from treating a patient at our facility.…”

Section: Introductionmentioning

confidence: 99%

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A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis

Dinger

Eerikäinen

Michel

et al. 2022

JCM

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Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, optimal treatment, and outcome of these patients remain unclear. This study aims to widen current knowledge about this “SEL subform” and to improve its clinical management. A systematic literature review according to the PRISMA guidelines using PubMed, Scopus, Web of Science, and Cochrane Library was used to identify publications before 7 November 2021 reporting on acute/rapidly progressing, severe SEL. The final analysis comprised 12 patients with acute, severe SEL. The majority of the patients were male (9/12) and multimorbid (10/12). SEL mainly affected the thoracic part of the spinal cord (11/12), extending a median number of 7 spinal levels (range: 4–19). Surgery was the only chosen therapy (11/12), except for one critically ill patient. Regarding the outcome, half of the patients regained independence (6/11; = modified McCormick Scale ≤ II). Acute, severe SEL is a rare condition, mainly affecting multimorbid patients. The prognosis is poor in nearly 50% of the patients, even with maximum therapy. Further research is needed to stratify patients for conservative or surgical treatment.

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Section: Systematic Review Of the Literaturementioning

confidence: 96%