An Unusual Cutaneous Tumor: African Histoplasmosis following Mudbaths: Case Report and Review

Tsiodras, Sotirios; Drogari‐Apiranthitou, Maria; Pilichos, Konstantinos; Leventakos, Konstantinos; Kelesidis, Theodoros; Buitrago, María J.; Πετρίκκος, Γεώργιος; Panayiotides, Ioannis G.

doi:10.4269/ajtmh.2012.11-0557

Cited by 20 publications

(20 citation statements)

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“…Numerous large yeast cells of 10-15 lm in diameter, which are thick-walled and exhibit narrow budding, are seen mainly in the giant cells and histiocytes; a few are seen extracellularly. 16 Molecular biological differentiation and fatty acid profiling have been found to be reliable methods of discriminating between the two. 7 Fungus can be cultured using any of the several laboratory media, such as Sabouraud's dextrose agar, brain-heart infusion agar, or brain-heart infusion blood agar.…”

Section: Discussionmentioning

confidence: 99%

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African histoplasmosis: the first report of an indigenous case in India

et al. 2014

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To the best of our knowledge, this case represents the first instance of African histoplasmosis to be reported from India. The occurrence of such a rare infection in an immunocompetent individual, who had not travelled elsewhere, raises the possibility of the indigenous existence of H. capsulatum var. duboisii in Kerala. Further studies of the ecology and epidemiology of this rare infection are essential.

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Section: Discussionmentioning

confidence: 99%

“…capsulatum. 16 Molecular biological differentiation and fatty acid profiling have been found to be reliable methods of discriminating between the two. 17 A few polymerase chain reaction (PCR) protocols have been developed for the specific diagnosis of H. capsulatum var.…”

Section: Discussionmentioning

confidence: 99%

African histoplasmosis: the first report of an indigenous case in India

et al. 2014

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“…Recent African literature mentions very few cases of histoplasmosis associated with HIV infection [ 4 ]. We have not noticed an increase in the number of cases since the advent of AIDS (1 to 2 per year on average), contrary to cryptococcosis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…These are the epithelioid and purulent granulomas, with lymphocytes, neutrophils, and many giant cells. The diagnosis has always allowed the detection of ovoid yeasts, typical of histoplasmic duboisii by histological examination [ 7 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo

Darré

Saka

Mouhari-Touré

et al. 2017

Journal of Pathogens

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Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1.8. The annual incidence was 1.1 cases. The mean age of the patients was 27.2 ± 0.4 years. All our patients were of social categories with a low socioeconomic level. HIV infection was known in 3 patients and one patient contracted tuberculosis. The clinical manifestations were cutaneous in 7 cases, cutaneous and mucous in 3 cases, cutaneous and lymph node in 3 cases, cutaneous and bone in 2 cases, and disseminated in 2 cases. The samples examined consisted of 14 cutaneous biopsies measuring 2-3 cm and 3 ganglionic biopsies each measuring 4 cm of major axis. Histologically, all cases were of chronic form made of granulomatous reaction with ovoid yeasts measuring between 1 and 2 microns. Despite the low frequency of this disease in our country, it should be kept constantly in mind before any granulomatous lesions, especially in the context of the HIV pandemic.

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“…About thirty cases were reported in Europe and all are imported were cases. [1][2][3][4][5][6][7][8] We report an immunocompetent Caucasian patient without identified immunodeficiency who had chronic pulmonary African histoplasmosis diagnosed four decades after a stay in western Africa.A 60-year-old man from Portugal was admitted to an emergency department in October 2006 for cough with clear sputum and chest pain. His medical history indicated a gastroduodenal ulcer.…”

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Imported African Histoplasmosis in an Immunocompetent Patient 40 Years after Staying in a Disease-Endemic Area

Richaud¹,

Chandesris²,

Benzaquen-Forner³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Histoplasmosis caused by Histoplasma capsulatum var. duboisii is a rare disease outside central and western Africa. In Europe, all cases are imported. We report a case of an African histoplasmosis with isolated pulmonary involvement in a non-immunocompromised patient that occurred 40 years after his stay in a disease-endemic area. The patient was given itraconazole. 18F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography was used to assess evolution during treatment. The outcome for the patient was favorable.African histoplasmosis may occur in persons without identified immunodeficiency, even a long time after exposure. African histoplasmosis caused by Histoplasma capsulatum var. duboiisi, a dimorphic fungus, is an invasive fungal disease endemic to central and western Africa and Madagascar. About thirty cases were reported in Europe and all are imported were cases. [1][2][3][4][5][6][7][8] We report an immunocompetent Caucasian patient without identified immunodeficiency who had chronic pulmonary African histoplasmosis diagnosed four decades after a stay in western Africa.A 60-year-old man from Portugal was admitted to an emergency department in October 2006 for cough with clear sputum and chest pain. His medical history indicated a gastroduodenal ulcer. He still visited his native country each year even though he had lived in France for 40 years. Forty years ago, he lived in Guinea-Bissau for two years during his military service. He is now a factory worker and enjoys gardening.The functional pulmonary symptoms occurred gradually without chills, sweats or fever for several weeks. Results of a clinical examination were normal. Oxygen saturation was 96%, temperature was 37 C, and there was no weight loss. A chest radiograph showed bilateral diffuse opacities with nodular cavitations. Chest computed tomography confirmed the presence of disseminated nodules (3-6 cm in diameter), some with cavitations and one of them calcified, but no adenopathy, pleural effusion, nor underlying parenchymal abnormalities (Figure 1).Laboratory tests showed normal blood cell counts: 5,400 leukocytes/mm 3 with 3,400 neutrophils/mm 3 , 1,400 lymphocytes/mm 3 , and 200 eosinophils/mm 3 . The C-reactive protein level was 138 mg/L, and serum levels of liver enzymes, bilirubin, and lactate dehydrogenase were within reference ranges. Sputum cultures were negative for bacteria, mycobacteria, and fungi. Serologic test results for aspergillosis and hydatidosis were negative. Abdominal and cardiac ultrasound and bronchoscopic evaluations show normal results. Bronchoalveolar lavage fluid contained 223 + 10 3 cells/mL, 93% alveolar macrophages, 5% lymphocytes, 2% neutrophils, and no neoplastic cells. Specific staining and/or cultures were negative for Pneumocystis jirovecii, mycobacteria, and bacterial microorganisms. Gomori-Grocott staining showed oval-shaped yeast 8-10 μm in diameter with narrow budding compatible with H. capsulatum var. duboisii (Figure 2). The culture yielded growth of a mycelial phase with tub...

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An Unusual Cutaneous Tumor: African Histoplasmosis following Mudbaths: Case Report and Review

Abstract: Abstract. African histoplasmosis, caused by Histoplasma capsulatum var. duboisii, is endemic in Africa. The disease usually involves the skin, subcutaneous tissue, and bones.

Cited by 20 publications

References 10 publications

African histoplasmosis: the first report of an indigenous case in India

African histoplasmosis: the first report of an indigenous case in India

Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo

Imported African Histoplasmosis in an Immunocompetent Patient 40 Years after Staying in a Disease-Endemic Area

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