An unusual detection of 2‐amino‐3‐(2‐chlorobenzoyl)‐5‐ethylthiophene and 2‐methylamino‐5‐chlorobenzophenone in illicit yellow etizolam tablets marked “5617” seized in the Republic of Ireland
Abstract:Benzodiazepines are a class of compounds used clinically to treat a variety of conditions including anxiety and insomnia. Their potential for abuse has led to a surge in their availability on the illegal drugs market. End users often rely on markings on illicit tablets to identify their contents. However, falsified tablets mimicking genuine pharmaceutical preparations often contain ingredients that differ from what people believe they are taking. The absence of any quality control of the content, purity, or st… Show more
“…The detection of the benzophenone and thiophene intermediates (used for the manufacturing of diazepam and etizolam)-especially in the absence of diazepam-was particularly surprising. 19 Another very interesting case was reported by Rosenberger and coworkers who analyzed a collection of three fizzy drink samples obtained from suppliers operating on the Internet. These so-called "dirty sprite" drinks are offered for sale and labeled to contain pharmaceutical substances promethazine and codeine.…”
Section: Medicines and Active Pharmaceutical Ingredientsmentioning
confidence: 96%
“…Three types of tablets sold illicitly as diazepam specimen were found to contain 2‐methylamino‐5‐chlorobenzophenone, 2‐amino‐3‐(2‐chlorobenzoyl)‐5‐ethylthiophene, and/or etizolam in various combinations. The detection of the benzophenone and thiophene intermediates (used for the manufacturing of diazepam and etizolam)—especially in the absence of diazepam—was particularly surprising 19 . Another very interesting case was reported by Rosenberger and coworkers who analyzed a collection of three fizzy drink samples obtained from suppliers operating on the Internet.…”
Section: Medicines and Active Pharmaceutical Ingredientsmentioning
“…The detection of the benzophenone and thiophene intermediates (used for the manufacturing of diazepam and etizolam)-especially in the absence of diazepam-was particularly surprising. 19 Another very interesting case was reported by Rosenberger and coworkers who analyzed a collection of three fizzy drink samples obtained from suppliers operating on the Internet. These so-called "dirty sprite" drinks are offered for sale and labeled to contain pharmaceutical substances promethazine and codeine.…”
Section: Medicines and Active Pharmaceutical Ingredientsmentioning
confidence: 96%
“…Three types of tablets sold illicitly as diazepam specimen were found to contain 2‐methylamino‐5‐chlorobenzophenone, 2‐amino‐3‐(2‐chlorobenzoyl)‐5‐ethylthiophene, and/or etizolam in various combinations. The detection of the benzophenone and thiophene intermediates (used for the manufacturing of diazepam and etizolam)—especially in the absence of diazepam—was particularly surprising 19 . Another very interesting case was reported by Rosenberger and coworkers who analyzed a collection of three fizzy drink samples obtained from suppliers operating on the Internet.…”
Section: Medicines and Active Pharmaceutical Ingredientsmentioning
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