An Unusual First Manifestation of Hodgkin Lymphoma: Epitrochlear Lymph Node İnvolvement—A Case Report and Brief Review of Literature

Abstract

Although epitrochlear lymph nodes may be enlarged as a part of generalized lymphadenopathy, isolated enlargement of epitrochlear lymph nodes is rarely seen. We describe Hodgkin’s lymphoma in a 55-year-old male who presented with isolated epitrochlear lymphadenopathy of his right arm. In the histopathological examination of the epitrochlear lymph node was a lymphocyte-rich Hodgkin lymphoma with a clinical grade (CS IA) diagnosed. The diagnosis was confirmed, via the bone marrow biopsy and positron emission tomography/computed tomography imaging, as pathological stage PS IA and clinical stage CS IA. Epitrochlear lymph node involvement, as a first presentation, is rarely seen in Hodgkin’s lymphoma. The aim of this study was to recapitulate the possible background diseases arising on the basis of an asymptomatic epitrochlear lymphadenopathy, to review the Hodgkin lymphoma presenting with primary epitrochlear lymphadenopathy in light of the literature, and to highlight the importance of a careful examination of the elbow site in routine physical examination.

Imaging of Anatomical Variants Around the Elbow

“…41 It represents a normal lymphatic superficial structure; however, some authors believe it is associated with rheumatoid disorders, tuberculosis, or lymphoproliferative pathologies. 42 43…”

Clinical significance and epidemiological evolution of epitrochlear lymphadenopathy in pre- and post-highly active antiretroviral therapy era: A systematic review of the literature

“…We identified 144 articles, of which 79 (including 507 subjects) were found to be eligible for inclusion. [ 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 ] Infections ( n = 356, 70.2%) and neoplasms ( n = 116, 22.9%) were the most common reported cau...…”

A rare involvement of epitrochlear lymph nodes in mantle cell lymphoma

“…Enlargement of epitrochlear lymph nodes is almost always pathological. Isolated enlargement of epitrochlear lymph nodes has also been reported 3. They can be enlarged in infectious conditions like HIV, leishmaniasis, syphilis, leprosy, cat scratch disease, tuberculosis, filariasis and inflammatory conditions like rheumatoid arthritis when the disease is active in the hands.…”