An unusual giant serpiginous lesion of secondary syphilis

Grimaux, Xavier; Ayoubi, Rida El; Clec’h, C. Le

doi:10.1590/abd1806-4841.20187251

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Several other atypical morphologies of secondary syphilis lesions have been reported as well. Among them are annular, nodular, pustular, acneiform, framboesiform, photosensitive SLE-like, corymbose, leukoderma, and pityriasis lichenoides-like morphologies [ 9 ] , many of which on their own in the absence of other diagnostic clues are not suggestive of syphilis.…”

Section: Discussionmentioning

confidence: 99%

The First Reported Case of Ocular Syphilis in an Iranian Patient

Fekri,

Salehi-Rad,

Nouri

et al. 2023

JOVR

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Purpose: To report the first case of ocular syphilis in an Iranian patient and discuss its diagnostic challenges. Case Report: A man in his mid-70s presented with progressive bilateral visual and auditory decline. He had previously lived in a Southeast Asian country for 10 years. Prior steroid therapies entailed no inflammation subsidence. His visual acuity at presentation was light perception OU. Funduscopic findings included severe vitritis, severe optic atrophy, diffuse retinal vascular occlusion, and diffuse retinal atrophy OU. Angiography demonstrated diffuse areas of retinal and choriocapillaris atrophy with no active choroiditis. Scaly cutaneous lesions were noted on his palms and soles – atypical findings of secondary syphilis. Serum analysis revealed an underlying syphilis infection. The cerebrospinal fluid sample was reactive to anti-syphilis antibodies, securing a neurosyphilis diagnosis. Two weeks of antibiotic therapy resulted in cutaneous lesions resolution and relative visual improvement despite extensive baseline retinal atrophic damage. Conclusion: Ocular syphilis can mimic numerous ocular inflammatory scenarios. In cases of ocular inflammation that is unresponsive to steroids, reconsidering alternative diagnoses, especially infections with the highest clinical relevance, is necessary. We stress the importance of acquiring patients’ sexual history, regardless of cultural barriers and the rarity of the entity in some regions.

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Section: Discussionmentioning

confidence: 99%