An Unusual Infection in an Immunocompetent Male of a Non-Endemic Area: Lessons from a Vacation

Neupane, Ritesh; Sharma, Mohit; Krishnamurthy, Mahesh; Sharma, Divakar; Thachil, R.; Lowman, G.

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6881

Cited by 1 publication

(1 citation statement)

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“…If these symptoms become chronic, there is a loss of lung function with a mortality of 30%. In our series, no case was suspected to have the onset of PH admitted with a diagnosis of bacterial pneumonia and primary lung cancer; for differential diagnosis, all patients underwent GeneXpert, and all in all, the result was negative [11].…”

Section: Discussionmentioning

confidence: 77%

Pulmonary Histoplasmosis in a Referral Hospital in Mexico City

Solís

Santibáñez

Olán

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Pulmonary histoplasmosis is caused by inhaling Histoplasma capsulatum. Less than 1% develops the disease. Risk factors in immunocompetent individuals are environmental exposures in endemic areas. The objective of this study is to determine the frequency, clinical, and microbiological characteristics in immunocompetent patients. A retrospective case series study of patients diagnosed with pulmonary histoplasmosis was performed in a respiratory care unit in Mexico City from 2000 to 2020. Each patient had bronchial lavage, and three patients underwent thoracoscopy for the lung tissue sample taken for the culture in Sabouraud Dextrose Agar. Twelve patients were identified, 8 males and 4 females; the predominant symptoms were fever (83%), dyspnea (75%), chest pain (66%), hemoptysis (41%), and weight loss (33%). The computed tomography of the chest showed the following findings: patchy consolidation 12 (100%), hilar adenopathy 6 (50%), pleural effusion 6 (50%), caverns 3 (25%), and solitary pulmonary nodule in one patient (8%). Histoplasma capsulatum was found in the culture of all twelve patients. The signs and symptoms of the disease are mediated by the immune status of the host. The clinical picture is often confused with systemic diseases. It is important to have a high degree of clinical suspicion to make a timely diagnosis.

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Section: Discussionmentioning

confidence: 77%