An Unusual Late Histologic Change Seen in the Intracutaneous Tuberculin Reaction*

Fisher, I

doi:10.1038/jid.1954.103

Cited by 14 publications

(3 citation statements)

References 2 publications

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“…Delayed cellular hypersensitivity reactions involve interactions of antigen with mononuclear histiocytes or macrophages and the production of delayed inflammatory lesions. Fisher (1954) has reported two cases of late dermal reaction from the Mantoux test in which there was palisading granuloma or GA. Earlier, Pascher, Sulzberger & Satenstein (1943) reported the same findings with the tuberculin test in one case, and more recently Beer & Wilson Jones (1966) reported GA after tubereulin tests. Schaumann & Seeberg (1948) demonstrated palisading granulomas after injection of lymphogranuloma venereum antigen.…”

Section: Discussionmentioning

confidence: 99%

Granuloma annulare and sarcoidosis

Umbert

Winkelmann

1977

Br J Dermatol

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Granuloma annulare (GA) and sarcoidosis are two diseases of unknown cause which involve the skin and whose basic pathology is a mononuclear histiocytic cellular reaction. Biopsy plays the major role in the diagnosis of both diseases, and no other routine laboratory test for either disease is currently available. Sarcoidosis is generally considered to be an allergic or immune granuloma with inconstant defects in cell-mediated immunity (Broom & MacLaurin, 1973). There have been no immunological studies of GA. We recently studied 14 cases and found circulating lymphokines (macrophage migration inhibition factor) in 11 which correlated with circulating macrophage migration inhibition factor in sarcoidosis (9 of 10 cases) (Umbert, Belcher & Winkelmann, 1976). The co-existence of GA and sarcoidosis in 5 patients suggests to us that there are very similar immunological reactions as well as pathology in both diseases and that the elucidation of the pathogenesis of one disease should aid in understanding the other. To our knowledge, there are no prior reports of systemic sarcoidosis coexisting with or manifesting the histological picture of GA. In this report we have demonstrated by clinical and histological criteria that GA and sarcoidosis can co-exist.

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Section: Discussionmentioning

confidence: 99%

Granuloma annulare and sarcoidosis

Umbert

Winkelmann

1977

Br J Dermatol

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“…2 Also, granuloma annulare-like changes were induced at the site of old intracutaneous tuberculin injections 6 months later. 5 Thus, histiocytes are activated at the late phase reaction, and may lead to the hyperproliferation in the present case. To our knowledge, this is the first case of fibrous histiocytoma following tuberculin test.…”

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confidence: 62%

Fibrous histiocytoma developing at the site of tuberculin skin test

Nomura¹,

Yamamoto²

2012

J Dermatol Case Rep

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“…It is likely that GA represents a reaction pattern to a wide variety of inflammatory stimuli. This concept is further supported by the observation that histologic findings consistent with GA have been reported at the sites of healing tuberculin skin tests (13–15). Although tuberculosis as an etiology was implicated in early reports, these have not been confirmed (16–18).…”

Section: Discussionmentioning

confidence: 97%

Granuloma Annulare of the Eyelid: A Case Report and Review of the Literature

Sandwich

Davis

1999

Pediatric Dermatology

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Granuloma annulare is a benign, relatively common dermatosis of childhood. Lesions typically occur on the extremities and resolve spontaneously over a period of several months to years. Localized facial involvement is rare. We report a case of granuloma annulare confined to the left eyelid. The literature on periocular granuloma annulare is reviewed. This diagnosis should be considered for any acquired papules of the periorbital area, especially if there is a history of antecedent trauma. Unnecessary surgical excision can then be avoided.

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An Unusual Late Histologic Change Seen in the Intracutaneous Tuberculin Reaction*

Cited by 14 publications

References 2 publications

Granuloma annulare and sarcoidosis

Granuloma annulare and sarcoidosis

Fibrous histiocytoma developing at the site of tuberculin skin test

Granuloma Annulare of the Eyelid: A Case Report and Review of the Literature

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