An unusual lesion in the right place

Abstract

Hidradenoma Papilliferum (HP) is a rare benign appendageal tumor occurring mainly in the anogenital region of adult women. Diagnosis is based on histopathology due to the lack of specific clinical features. The treatment of choice is total excission. We describe a rare case of a 65-year-old woman who presented to our outpatient department with an enlarging nodule of the left labia majora of her vulva. The histological findings were consistent with the diagnosis of Hidradenoma Papilliferum.

Hidradenoma papilliferum of the hymen: a case report

“…Today, most authors state that these lesions originate from breast-like apocrine glands [ 10 ]. In histopathological examination, it is defined as lesions, which are independent of the epidermis layer of the skin and are covered with secretory cells containing tubular structure, containing cystic and papillary structures, and also containing breast-like accessory glands [ 10 , 11 ]. Several studies have identified HPV types 16, 31, 33, 53 and 56 DNA in hidradenoma papilliferum tissue.…”

Ectopic hidradenoma papilliferum

“…Many cases of HP have been reported since it was first described by Werth in 1878. 5 However, very few cases of ectopic HP have been reported in male patients. 4 Ectopic HP can occur on the eyelids, orbit, nose, breast, chest, abdomen, and scalp.…”

“…Such histopathology findings are similar to those observed in intraductal papilloma of the breast and some authors believe that accessory mammary-like glands may have a role in the histogenesis of the tumor. 5 …”

“…Histological examination is required for the accurate diagnosis of HP. 5 The differential diagnosis for ectopic HP includes benign adnexal tumors, such as apocrine hidrocystoma and syringocystadenoma papilliferum. 5 In our case, we included clinical differential diagnosis of basal cell carcinoma, epidermal cyst, and pyogenic granuloma.…”

“…Five cases of ductal carcinoma in situ arising within a pre-existing hidradenoma papilliferum have been documented, and two cases have reported invasive carcinomas arising from HP (malignant perianal papillary hidradenoma and vulvar adenosquamous carcinoma). 5 …”