An Unusual Maxillary Tumor with Tubuloductal Epithelial Structures, Solid Epithelial Nests and Stromal Odontogenic Ameloblast-Associated Protein Deposits. Tubuloductal/Syringoid Variant of Central Odontogenic Fibroma with Amyloid?

Koutlas, Ioannis G.; Ponce, Katia Julissa; Wazen, Rima; Nanci, Antonio

doi:10.1007/s12105-021-01369-7

Cited by 3 publications

(1 citation statement)

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“…The proliferation of odontogenic epithelial cells rather than the usual inactive status can be seen in the NCLC-CEOT cases. Based on the recent study [ 47 ], such abundant proliferating epithelial components are away from the inactive status and can hardly be ignored in the diagnosis of these NCLC-CEOT/AR-COF cases. The diagnosis of COF, a mesenchymal tumor, seems not to be representative of the histopathological features of the disease possessing the proliferating odontogenic epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum?

Tseng

Wang

et al. 2021

Front. Oral. Health

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Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases.

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Section: Discussionmentioning

confidence: 99%