An unusual metastasis of lung adenocarcinoma: Biceps brachii muscle

Sarıaydın, Muzaffer; Günay, Ersin; Ulaşlı, Sevinç Sarınç; Günay, Si̇bel; Yavaş, Betül Demirciler; Tokyol, Çiğdem; Uysal, Mükremın; Ünlü, Mehmet

doi:10.4103/0970-2113.192857

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…The histological appearance of tumor foci was very similar in the different animals, irrespective of the age of the mice (Figure 1c). It is worth noting that between the 45th and the 50th week of age, 25% of K-Ras G12D mice develop extrathoracic metastases (Figure 1d) in the liver, skeletal muscle, and stomach, which are the same sites of cancer-cell dissemination found in patients affected by NSCLC [78,79].…”

Section: K-ras G12d Transgenic Mice Are a Valuable Pre-clinical Modelmentioning

confidence: 74%

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Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas

et al. 2020

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Non-small cell lung cancer (NSCLC) is still the leading cause of cancer death worldwide. Despite the introduction of tyrosine kinase inhibitors and immunotherapeutic approaches, there is still an urgent need for novel strategies to improve patient survival. ROS1, a tyrosine kinase receptor endowed with oncoantigen features, is activated by chromosomal rearrangement or overexpression in NSCLC and in several tumor histotypes. In this work, we have exploited transgenic mice harboring the activated K-Ras oncogene (K-RasG12D) that spontaneously develop metastatic NSCLC as a preclinical model to test the efficacy of ROS1 immune targeting. Indeed, qPCR and immunohistochemical analyses revealed ROS1 overexpression in the autochthonous primary tumors and extrathoracic metastases developed by K-RasG12D mice and in a derived transplantable cell line. As proof of concept, we have evaluated the effects of the intramuscular electroporation (electrovaccination) of plasmids coding for mouse- and human-ROS1 on the progression of these NSCLC models. A significant increase in survival was observed in ROS1-electrovaccinated mice challenged with the transplantable cell line. It is worth noting that tumors were completely rejected, and immune memory was achieved, albeit only in a few mice. Most importantly, ROS1 electrovaccination was also found to be effective in slowing the development of autochthonous NSCLC in K-RasG12D mice.

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Section: K-ras G12d Transgenic Mice Are a Valuable Pre-clinical Modelmentioning

confidence: 74%

“…It is worth noting that between the 45th and the 50th week of age, 25% of K-Ras G12D mice develop extrathoracic metastases ( Figure 1 d) in the liver, skeletal muscle, and stomach, which are the same sites of cancer-cell dissemination found in patients affected by NSCLC [ 78 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas

et al. 2020

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“…If drug-resistant pain from muscle metastases persists, surgical resection would be appropriate depending on the number, site, and dimensions, which are independent of the histologic type. Treatment for muscle metastasis is often palliative, and the presence of skeletal muscle metastasis is associated with poor survival, usually less than one year [ 10 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

A Case Report and Literature Review of Skeletal Muscle Metastasis of Non-small Cell Lung Cancer

Youn,

Srinivasan,

Kuta

et al. 2024

Cureus

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Non-small cell lung cancer metastasis to skeletal muscle is an uncommon occurrence. Lung cancers are more likely to spread to the brain, bone, liver, and adrenals. Here, we present a rare case of non-small cell lung cancer metastasis to the skeletal muscle in a 54-year-old male. In addition, we present a literature review on skeletal metastasis of non-small cell lung cancer. The most frequent presentation of skeletal muscle metastasis is muscular pain with or without swelling. The mechanism of metastasis to muscle is not well understood; it is theorized that hematogenous spread is the most likely route. As with our patient, the presence of skeletal muscle mass is considered an aggressive disease with poor survival, usually less than one year. The treatment for muscle metastasis is often palliative in the form of radiation therapy, chemotherapy, or surgical removal of the mass.

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“…The most commonly accepted hypothesis supports the idea of spread via vasculature. It suggests that tumor embolism is the cause of metastasis in the muscles [ 6 ]. The most common sites of skeletal muscle metastasis of lung cancer are the thigh, iliopsoas, and paraspinous muscles.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

Weeraddana¹,

Walgamage²,

Elkabbani³

et al. 2023

Cureus

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Lung cancer is one of the leading causes of cancer-related death worldwide. Lung cancer commonly metastasizes to the liver, bone, and brain, but metastasis to skeletal muscles is rare. The development of metastasis in skeletal muscles indicates stage IV disease with a poor prognosis. The most effective treatment strategy is unclear. Palliative radiotherapy is often used to treat skeletal muscle metastases, and patient survival is poor, with an average survival of one year. Here we discuss the case of a 76-year-old female diagnosed with lung adenocarcinoma with metastasis to the trapezius muscle. Initially, she was treated with stereotactic body radiotherapy for stage T1 lung adenocarcinoma. Her follow-up surveillance positron emission tomography (PET) scan in 11 months showed an abnormal focal area of increased activity localizing to the long head of the right triceps muscle. The diagnosis was confirmed with an ultrasound-guided biopsy of the trapezius muscle. Following that, the patient underwent wedge resection of the right middle and upper lobe of the lung and partial right trapezius resection. Afterward, she was given radiation therapy at the tricep resection site. She remained disease-free for four years after excision and radiation therapy.

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An unusual metastasis of lung adenocarcinoma: Biceps brachii muscle

Cited by 7 publications

References 14 publications

Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas

Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas

A Case Report and Literature Review of Skeletal Muscle Metastasis of Non-small Cell Lung Cancer

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

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