An unusual ocular emergency in severe dengue

Nagaraj, Kalpana Badami; Jayadev, Chaitra; Yajmaan, Soumya; Prakash, Savitha

doi:10.4103/0974-9233.142276

Cited by 17 publications

(13 citation statements)

References 4 publications

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“…[15,16] Other very rare associations are ptosis and periorbital ecchymosis and globe rupture. [3,17,18] Our study is similar to that by Kapoor et al [15] and Hussain et al [3] with regard to male preponderance. The mean age group of our study is 32 years that is also similar in other studies.…”

Section: Discussionsupporting

confidence: 91%

“…The onset of ocular manifestations in our study correlated with the nadir of thrombocytopenia as seen in other studies. [3,9,13,18] The most common ocular manifestation in our patients was subconjunctival hemorrhage followed by retinal hemorrhages. It was similar to the studies by Kapoor et al [15] and Hussain et al; [3] however, in contrast, one patient presented with optic neuropathy in our study.…”

Section: Discussionmentioning

confidence: 70%

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Ocular manifestations of dengue fever

Sujatha¹,

Nousheen²,

Nazlin³

et al. 2015

Int J Med Sci Public Health

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Background: Dengue fever, borne by Aedes aegypti mosquito, is one of the most common and most prevalent forms of flavivirus infections in humans, endemic in tropics and warm temperate regions of the world. We report a spectrum of ocular manifestations of dengue fever along with its associated laboratory findings. Objective: To study the ocular manifestations associated with dengue fever. Materials and Methods: This study was conducted in 120 patients hospitalized with diagnosis of dengue fever over a period of 6 months from April 2014 to September 2014. All patients underwent complete evaluation with respect to systemic examination, ophthalmic examination in

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 70%

Ocular manifestations of dengue fever

Sujatha¹,

Nousheen²,

Nazlin³

et al. 2015

Int J Med Sci Public Health

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“…The vitreous, suprachoroidal and retrobulbar hemorrhage could have multiple probable mecahnisms, including occurred spontaneous hemorrhage [10] due to thrombocytopenia and/or due to trauma from vigorous rubbing of the eye. There has been one case report [11] of ruptured globe following proptosis, as seen in our patient. However, ruptured globe following proptosis secondary to retrobulbar hemorrhage with a normal platelet count in the conalescent phase of dengue fever, as seen in our patient, has been hitherto unreported.…”

Section: Discussionsupporting

confidence: 53%

Globe Rupture

2016

IJSR

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Dengue fever, also known as breakbone fever, is a mosquito-borne tropical disease caused by the dengue virus (DENV), a flavivirus, spread by Aedes aegypti mosquito. Most people infected with dengue virus are asymptomatic or only have mild symptoms such as an uncomplicated fever. Severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage. Ophthalmic manifestations can involve both the anterior and posterior segment and are usually associated with a low platelet count. We report an ocular emergency of acute retrobulbar, intrabulbar hemorrhage, and globe rupture as a rare complication of a patient with dengue in the convalescent phase, with normal platelet counts.

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“…Like ZIKV, dengue virus (DENV) can also cause ocular pathology, leading to the emergence of a new terminology "dengue eye disease" [56]. Clinical studies have shown that DENV can cause retinochoroiditis, vasculitis, choroidal neovascularisation, subconjunctival hemorrhage, ecchymosis, retinal artery occlusion, and in some unusual cases even globe rupture [56,57]. However, DENV infection in cornea is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Interferon-stimulated gene 15 (ISG15) restricts Zika virus replication in primary human corneal epithelial cells

Singh

Farr

et al. 2019

The Ocular Surface

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Purpose: Zika virus (ZIKV) has emerged as an important human pathogen causing ocular complications. There have been reports of the shedding of ZIKV in human as well as animal tears. In this study, we investigated the infectivity of ZIKV in corneal epithelial cells and their antiviral immune response. Methods: Primary human corneal epithelial cells (Pr. HCECs) and an immortalized cell line (HUCL) were infected with two different strains of ZIKV (PRVABC59 & BeH823339) or dengue virus (DENV, serotypes 1-4). Viral infectivity was assessed by immunostaining of viral antigen and plaque assay. qRT-PCR and immunoblot analyses were used to assess the expression of innate inflammatory and antiviral genes. Supplementation of recombinant ISG15 (rISG15) and gene silencing approaches were used to elucidate the role of ISG15 in corneal antiviral defense. Results: Pr. HCECs, but not the HUCL cells, were permissive to both ZIKV strains and specifically to DENV3 infection. ZIKV induced the expression of viral recognition receptors (TLR3, RIG-I, & MDA5), and genes involved in inflammatory (CXCL10& CCL5) and antiviral (IFNs, MX1, OAS2, ISG15) responses in Pr. HCECs. Furthermore, ZIKV infection caused Pr. HCECs cell death, as evidenced by TUNEL staining. Silencing of ISG15 increased ZIKV infectivity while supplementation with rISG15 reduced ZIKV infection by direct inactivation of ZIKV and inhibiting its entry. Conclusions: Our study demonstrates for the first time, that ZIKV virus can readily infect and replicate in Pr. HCECs. Therefore, ZIKV may persist in the cornea and pose the potential risk of transmission via corneal transplantation.

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An unusual ocular emergency in severe dengue

Cited by 17 publications

References 4 publications

Ocular manifestations of dengue fever

Ocular manifestations of dengue fever

Globe Rupture

Interferon-stimulated gene 15 (ISG15) restricts Zika virus replication in primary human corneal epithelial cells

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