An unusual presentation of a cystic duplication of the sigmoid colon entirely lined with squamous epithelium

Rodesch, Gregory; Dargent, Jean Louis; Haller, Annick; Cassart, Marie; Avni, Freddy; Cos, T.; Herreweghe, I. Van; Deleuze, Jean; Lingier, Pierre

doi:10.1016/j.jpedsurg.2009.05.029

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…Future studies might prove that lack of ΔNp63 expression in the endoderm is not only sufficient but also necessary for intestinal cell differentiation. Last, expression of ΔNp63 in early colorectal progenitors also provides developmental insight into the cell of origin of squamous cell metaplasia and squamous cell carcinoma, rare but distinct disease entities of colorectal epithelium (39)(40)(41). Because p63 is a master regulator of stratified epithelial development (42), either persistence of ΔNp63-positive progenitor cells or regression to a primitive, ΔNp63-positive state may reflect the colorectal epithelium's latent potential to recall its developmental origins and differentiate aberrantly into the squamous cell lineage.…”

Section: Discussionmentioning

confidence: 99%

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

Pignon

Grisanzio

Geng

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

196

194

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The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63 isoform, is a marker of basal epithelial cells and is required for normal development of several epithelial tissues, including the bladder and prostate glands. Although p63-expressing cells are proposed to be the stem cells of the developing prostate epithelium and bladder urothelium, cell lineages in these endoderm-derived epithelia remain highly controversial, and rigorous lineage tracing studies are warranted. Here, we generated knock-in mice expressing Cre recombinase (Cre) under the control of the endogenous ΔNp63 promoter. Heterozygote ΔNp63 +/Cre mice were phenotypically normal and fertile. Cremediated recombination in ΔNp63 +/Cre ;ROSA26 EYFP reporter mice faithfully recapitulated the pattern of ΔNp63 expression and were useful for genetic lineage tracing of ΔNp63-expressing cells of the caudal endoderm in vivo. We found that ΔNp63-positive cells of the urogenital sinus generated all epithelial lineages of the prostate and bladder, indicating that these cells represent the stem/ progenitor cells of those epithelia during development. We also observed ΔNp63 expression in caudal gut endoderm and the contribution of ΔNp63-positive cells to the stem/progenitor compartment of adult colorectal epithelium. Because p63 is a master regulator of stratified epithelial development, this finding provides a unique developmental insight into the cell of origin of squamous cell metaplasia and squamous cell carcinoma of the colon.large intestine | hindgut | genitourinary tract

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Section: Discussionmentioning

confidence: 99%

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

Pignon

Grisanzio

Geng

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

196

194

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“…Tubular colon duplications are often associated with abnormalities of the anus, vagina or penis 7 8. Also, there may be an association between colon duplication and colovesical fistula 9 10.…”

Section: Discussionmentioning

confidence: 99%

A case of sigmoid colon duplication in an adult woman

Al-Jaroof

Al-Zayer

Meshikhes³

2014

BMJ Case Reports

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Colonic duplication is a rare congenital anomaly that is often diagnosed in childhood, but may go unrecognised until adulthood. It often presents with chronic abdominal pain and constipation, and the preoperative diagnosis may be difficult. We present a case of sigmoid duplication in a 33-year-old Indonesian woman who presented with right-sided colicky abdominal pain and vomiting. Clinical examination was unremarkable and radiological investigations raised the possibility of a giant colon diverticulum. The patient underwent exploratory laparotomy that revealed a tubular sigmoid duplication. A sigmoid colectomy with end-to-end anastomosis was performed. She was discharged a week later and remained well at 1 year follow-up. Colon duplications rarely present in adult life and the accurate diagnosis is often made at laparotomy.

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“…Histopathologically, intestinal duplications have at least one outer muscular layer together with an inner gastrointestinal mucosal lining, which may be composed of several different types of gastrointestinal mucosa. However, ileal duplication cyst lined by ciliated columnar and squamous epithelium has been rarely reported in the literatures [6, 7]. Here, in our case with tubular ileal duplication, there was coexistence of intestinal columnar and esophageal squamous epithelium in the duplicated segment.…”

Section: Discussionmentioning

confidence: 51%

Dynamic Change of Intestinal Duplication in an Adult Patient: A Case Report and Literature Review

Shah

Sun

et al. 2012

Case Reports in Medicine

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Intestinal duplication in an adult is an uncommon congenital abnormality because only minority of cases present in adulthood. More than 80% of cases occur before the age of two years as an acute abdomen, bowel obstruction or other complications associated with it. Duplication has two types, either cystic or tubular. Here, we report a case of an adult who was diagnosed preoperatively on CT scan as tubular intestinal duplication. CT images showed change in the morphology of the cystic mass after one week of antibiotics administration. On histopathological analysis, the resected duplicated segment had esophageal epithelium in addition to the intestinal gland. So far, we found no report describing CT findings of dynamic change of ileal duplication in the English literatures.

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An unusual presentation of a cystic duplication of the sigmoid colon entirely lined with squamous epithelium

Cited by 11 publications

References 13 publications

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

A case of sigmoid colon duplication in an adult woman

Dynamic Change of Intestinal Duplication in an Adult Patient: A Case Report and Literature Review

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