An Unusual Presentation of Aggressive Primary Invasive Adenocarcinoma of Lung

Thimmareddygari, Divya Mounisha; Chan, Kok Hoe; Patel, R.; Bellary, Sharath; Sharma, Hemlata; Miller, Richard A.

doi:10.1016/j.amjms.2020.09.014

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…The pan-cancer RNA-seq data of TCGA and GTEx with toil processed uniformly were downloaded from UCSC XENA (https://xenabrowser.net/datapages/) [10][11][12][13]. Level 3 HTSeq-FPKM and HTSeq-Count data of the LUAD samples were obtained from the TCGA website (https://portal.gdc.cancer.gov/repository) for further analysis.…”

Section: Rna-sequencing Data and Bioinformatics Analysismentioning

confidence: 99%

High expression of VTA1 is an adverse prognostic factor in lung adenocarcinoma

Xingang Sun,

Ruixin Wu,

Xinjun Guan

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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Lung adenocarcinoma (LUAD) is a common pathological type of non-small cell lung cancer; identifying preferable biomarkers has become one of the current challenges. Given that VTA1 has been reported associated with tumor progression in various human solid cancers but rarely reported in LUAD, herein, RNA sequencing data from TCGA and GTEx were obtained for analysis of VTA1 expression and differentially expressed gene (DEG). Furthermore, functional enrichment analysis of VTA1-related DEGs was performed by GO/ KEGG, GSEA, immune cell infiltration analysis, and protein-protein interaction (PPI) network. In addition, the clinical significance of VTA1 in LUAD was figured out by Kaplan-Meier Cox regression and prognostic nomogram model. R package was used to analyze incorporated studies. As a result, VTA1 was highly expressed in various malignancies, including LUAD, compared with normal samples. Moreover, high expression of VTA1 was associated with poor prognosis in 533 LUAD samples, as well as T stage T2&T3&T4, N stage N1&N2&N3, M stage M1, pathologic stage II&III&IV, and residual tumor R1&R2, et al. (P < 0.05). High VTA1 was an independent prognostic factor in Cox regression analysis; Age and cytogenetics risk were included in the nomogram prognostic model. Furthermore, a total of 4232 DEGs were identified between the high-and the low-expression group, of which 736 genes were up-regulated and 3496 genes were down-regulated. Collectively, high expression of VTA1 is a potential biomarker for adverse outcomes in LUAD. The DEGs and pathways recognized in the study provide a preliminary grasp of the underlying molecular mechanisms of LUAD carcinogenesis and progression.

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Section: Rna-sequencing Data and Bioinformatics Analysismentioning

confidence: 99%

High expression of VTA1 is an adverse prognostic factor in lung adenocarcinoma

Xingang Sun,

Ruixin Wu,

Xinjun Guan

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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“…Invasive adenocarcinoma of the lung (IAC) is a malignantly transformed epithelial tumor that displays adenoidal differentiation, secretes mucus, and expresses alveolar cell markers. On a pathological level, this tumor type infiltrates the surrounding tissue, contains myofibroblasts, and exhibits growth patterns such as papillae, micropapillae, and solid, all of which exceed a size of 5 mm 3 . Surgical resection is the main treatment for resectable tumors in early stages of NSCLC.…”

Section: Introductionmentioning

confidence: 99%

“…On a pathological level, this tumor type infiltrates the surrounding tissue, contains myofibroblasts, and exhibits growth patterns such as papillae, micropapillae, and solid, all of which exceed a size of 5 mm. 3 Surgical resection is the main treatment for resectable tumors in early stages of NSCLC. Adjuvant therapy, which includes radiation, chemotherapy, and targeted therapy, is added whenever the tumor is considered resectable.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of postoperative folate receptor‐positive circulating tumor cells (FR + CTCs) for long‐term prognosis in patients with invasive adenocarcinoma (IAC) of the lung

Ma,

Zhou,

Wang

et al. 2024

Thoracic Cancer

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BackgroundThe aim of the study was to evaluate the prognostic value of postoperative folate receptor‐positive circulating tumor cell (FR + CTC) detection in patients with stage I–III invasive adenocarcinoma (IAC) treated with surgery.MethodsPatients with lung adenocarcinoma (LUAD) who underwent surgical resection in Peking University Cancer Hospital and received postoperative FR + CTC analysis from July 2016 to January 2021 were retrospectively collected. Comparisons between or among groups were made using the Kruskal‐Wallis or Mann–Whitney U tests. Survival curves were estimated using the Kaplan–Meier method and compared using the log‐rank test. Cox proportional hazard regression analyses were performed to explore the factors predicting recurrence and survival.ResultsThere were significant differences between the high and low groups in terms of age (p = 0.002), postoperative CA199 (p = 0.038), and postoperative SCC (p = 0.024). There were no significant differences in the other indicators (all p>0.05). N stage 1, N stage 2, and neoadjuvant therapy (NAT) were independent risk factors for disease recurrence and death; pleural invasion (PI), and nerve invasion were independent risk factors for death. The Kaplan–Meier curve showed a notable trend for a worse disease‐free survival (DFS) or overall survival (OS) for patients with high levels of FR + CTCs in our study, but none of these were statistically significant.ConclusionThe detection of FR + CTCs postoperatively was an independent predictor of recurrence in patients treated for stage I–III IAC. Standardized detection methods and optimal time points for assessment should be established in future studies.

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Pulmonary adenocarcinoma mimicking rheumatoid lung and delaying diagnosis for 8 months

Spalgais¹,

Mrigpuri²,

Kulshrestha³

et al. 2022

The Egyptian Journal of Chest Diseases and Tuberculosis

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The clinical and radiological findings of adenocarcinoma and rheumatoid lung disease are non-specific and similar. The final diagnosis should be confirmed by histopathology. We present an adenocarcinoma of lung in known rheumatoid patient presenting as cough and breathlessness for 8 months. The CT chest revealed multiple consolidations, bronchectasis and honeycombing with two times bronchoscopic biopsy negative. All non-resolving lesions with non-specific symptoms should be investigated for all possible causes including malignancy. We advised to do CT guided biopsy in such cases even after bronchial biopsy negative as it has higher yield and cost effective test.

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An Unusual Presentation of Aggressive Primary Invasive Adenocarcinoma of Lung

Cited by 4 publications

References 24 publications

High expression of VTA1 is an adverse prognostic factor in lung adenocarcinoma

High expression of VTA1 is an adverse prognostic factor in lung adenocarcinoma

Clinical significance of postoperative folate receptor‐positive circulating tumor cells (FR + CTCs) for long‐term prognosis in patients with invasive adenocarcinoma (IAC) of the lung

Pulmonary adenocarcinoma mimicking rheumatoid lung and delaying diagnosis for 8 months

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