An unusual presentation of diffuse large B‐cell lymphoma with ureteric involvement: A case report

Abstract

Introduction Non‐Hodgkin's lymphomas are a heterogeneous group of malignancies in the lymphoid system and ureteric involvement by non‐Hodgkin's lymphoma is very rare. Case presentation We present a 37‐year‐old male, presenting with lower urinary tract symptoms and right flank pain. Initially, he presented with lower urinary tract symptoms without having any evidence of urinary tract infection and was managed for nonspecific cystitis. His ureteral histopathology report indicated a diffused infiltration by malignant lymphoid cells and the final diagnosis revealed diffuse large B‐cell lymphoma. His positron‐emission tomography scan indicated stage 4 disease with skeletal involvement and he was then treated by rituximab, cyclophosphamide, liposomal doxorubicin, vincristine, and methylprednisolone chemotherapy. Later, he was also diagnosed with central nervous system lymphoma and died during his stay in the hospital. Conclusion Primary diffuse large B‐cell lymphoma of the ureter is extremely rare; however, it should be considered in the differential diagnosis for patients presenting with obstructive uropathy as its early detection is crucial for diagnostic and therapeutic treatment.

Retroperitoneal lymphadenopathy: An underappreciated contributor to acute kidney failure in patients with cancer

“…This case report provides a vivid illustration of the intricate diagnostic challenges faced in identifying non-dilated obstructive nephropathy, especially when the characteristic feature of hydronephrosis is absent on imaging. 5 Complete bilateral obstruction can lead to a rapid and irreversible decline in kidney function unless the obstruction is promptly alleviated. Therefore, a thorough and expedient investigation into the cause of obstruction is crucial.…”

“…This case report provides a vivid illustration of the intricate diagnostic challenges faced in identifying non-dilated obstructive nephropathy, especially when the characteristic feature of hydronephrosis is absent on imaging. 5…”

Ultrasonographic diagnosis of a lymphomatous lymph node presumptively infiltrating the ureter causing hydronephrosis in a 3‐year‐old dog

“…Another possibility that cannot be excluded, but that is considered much less likely, is a secondary mass of ureteral origin closely associated and not directly connected with the lymph node. Primary ureteral lymphomatous masses are very rare in humans, [19][20][21][22][23] and are typically considered a primary differential only when there is not concurrent, nearby lymphadenopathy. 24 An interesting feature of this case is the absence of azotemia with complete destruction of the left renal parenchyma.…”