An unusual presentation of lacrimal gland pleomorphic adenoma

Iyeyasu, Josie Naomi; Reis, Fabiano; Altemani, Albina; Carvalho, Keila Monteiro de

doi:10.1590/s0034-72802013000500012

Cited by 5 publications

(8 citation statements)

References 9 publications

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“…However, there is no clear gender predominance. [7] The clinical presentation is usually a slowing growing painless palpable mass in the upper outer quadrant of the orbit with inferonasal displacement of the globe. [1,2,8,9] They can also have epiphora, increase in intraocular pressure, visual impairment and diplopia.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

Kazi¹,

Parameshwar²,

Kavishwar³

et al. 2021

Ann of Pathol and Lab Med

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Among the various tumours affecting the lacrimal gland, pleomorphic adenomas though most common can present clinically and radiologically as worrisome tumours. Histopathologic diagnosis hence is very critical for these tumours. We present a case of pleomorphic adenoma of the lacrimal gland which we encountered at our institutes. The patient was a 46-year-old male who came with complaints of a gradually progressing swelling in the right eye not associated with much pain or significant loss of vision. MRI revealed a large lobulated extrachoanal mass causing mass effect and scalloping of the adjacent bony structures. An excision biopsy was done and sent for histopathological examination. Histologically the tumour showed a biphasic morphology comprising of epithelial (ductal and myoepithelial) and chondromyxoid stromal components. Immunohistochemistry showed positivity for pan CK and CK 7 in ductal epithelial cells, p63 and S100 in myoepithelial cells and a low Ki67 index. On the basis of immunohistochemistry profile along with clinicoradiological correlation a final diagnosis of pleomorphic adenoma of the lacrimal gland was made. The patient post-surgery was doing well but was lost to follow up. It can thus be seen that is it absolutely necessary to accurately diagnose these benign but clinically misconceiving rare tumours of the lacrimal gland for appropriate management of such patients.

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Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

Kazi¹,

Parameshwar²,

Kavishwar³

et al. 2021

Ann of Pathol and Lab Med

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“…Sobre las bases de su apariencia histológica y la proporción relativa entre el componente epitelial y el estroma se determinó que correspondía a un adenoma pleomórfico predominantemente celular con escasos focos de componentes mixoide, condroide y hialino 8 . Su diagnóstico diferencial abarca varias patologías como el linfoma, el carcinoma adenoide quístico, la dacrioadenitis crónica, la sarcoidosis, el hemangioma cavernoso, el síndrome de Sjögren y el schwannoma intralagrimal, como relatan Iyeyasu et al 18 . Si bien el adenoma pleomórfico se clasifica como un tumor benigno, tiene tendencia a recurrir después de su primer tratamiento quirúrgico, con riesgo de transformación maligna 19,20 .…”

Section: Discussionunclassified

Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Rosso¹,

Samar²,

Rodolfo³

et al. 2020

RevFacOdont

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Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions. Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation.

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“…Computed tomography (CT) and magnetic resonance imaging (MRI) scans are ideal, with MRI as the preferred method for visualization of the surrounding bone and examination for intracranial infiltration 6 . On MRI, pleomorphic adenomas appear as isointense lesions with regular margins and angles 4 . For a PA, a well circumscribed mass identified within the lacrimal fossa is usually seen (See Fig.…”

Section: Radiographic Imagingmentioning

confidence: 99%

“…The most common is the benign mixed tumor or pleomorphic adenoma (PA), a benign mixed tumor consisting of epithelial and mesenchymal components 2 . These neoplasms characteristically presents with slow, painless enlargement of the lateral portion of the upper eyelid in the 3rd and 4th decades of life, with no clear gender predominance 4 . Although benign, these epithelial tumors have a propensity to recur and undergo malignant transformation if incompletely excised, leading to increased morbidity in these patients 5 …”

Section: Introductionmentioning

confidence: 99%

Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics

Harrison

Pittman

Cummings

2018

Saudi Journal of Ophthalmology

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Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. There is a tendency to reoccur, especially if there is an incomplete excision, and rarely, malignant transformation to carcinoma ex pleomorphic adenoma can occur, which has a much poorer prognosis. The molecular genetics of lacrimal gland pleomorphic adenomas have only recently been studies, but appear to display similar genetic aberration found in the salivary gland counterparts.

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An unusual presentation of lacrimal gland pleomorphic adenoma

Cited by 5 publications

References 9 publications

Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics

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