An Unusual Presentation of Multiple Myeloma with High Grade Fever and Loss of Consciousness

Naderi, Hassan; Sheybani, Fereshte; Khodashahi, Rozita; Sajjadi, Sareh; Miradi, Mahdi

doi:10.9734/ijmpcr/2016/22934

Cited by 2 publications

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“…Meningitis in particular has been the presenting symptom of MM in a handful of cases. A summary table of bacterial syndromes as the first feature of MM can be found in the paper published by Naderi et al, which reported only five instances of meningitis as the manifestation of MM [ 17 ]. Myeloma patients may also be prone to infection by fungi, such as the emerging C. auris .…”

Section: Discussionmentioning

confidence: 99%

A Case of Multiple Myeloma Presenting as Streptococcus pneumoniae Meningitis with Candida auris Fungemia

et al. 2018

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Multiple myeloma (MM), a plasma cell neoplasm, has a typical presenting pattern consisting of bone pain, renal failure, anemia, and/or hypercalcemia. Even though MM is a cancer that impairs the immune system, rarely is a systemic infection the first sign of disease. In this case report, our patient presented with altered mental status due to meningitis and was later diagnosed with MM. Furthermore, we display a case of a rare but emerging and serious fungus, Candida auris, that the patient developed during his inpatient stay. This is the first such record of C. auris in an MM patient.

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Section: Discussionmentioning

confidence: 99%

A Case of Multiple Myeloma Presenting as Streptococcus pneumoniae Meningitis with Candida auris Fungemia

et al. 2018

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Bacterial Meningitis as the First Presentation of Multiple Myeloma

Zutushi

Shukla

Acharya

et al. 2022

Journal of the Scientific Society

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Multiple myeloma (MM) is a monoclonal gammopathy. Patients with MM are vulnerable to infections, especially by encapsulated bacteria. These infections have been associated with severe morbidity and mortality in MM. A key underlying cause of the immune system's decline in MM is insufficient production of polyclonal immunoglobulin, which manifests as severe hypogammaglobulinemia. An acute bacterial infection is rarely the first sign of the disease. We present a case of a 65-year-old male who presented to us with fever and disorientation. Clinical examination revealed signs of meningeal irritation. Cerebrospinal fluid study confirmed bacterial meningitis. Associated features such as renal failure, high erythrocyte sedimentation rate, hyperglobulinemia, and anemia lead to suspicion of MM which was later confirmed by serum electrophoresis.

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An Unusual Presentation of Multiple Myeloma with High Grade Fever and Loss of Consciousness

Cited by 2 publications

References 0 publications

A Case of Multiple Myeloma Presenting as <b><i>Streptococcus pneumoniae</i></b> Meningitis with <b><i>Candida auris</i></b> Fungemia

A Case of Multiple Myeloma Presenting as <b><i>Streptococcus pneumoniae</i></b> Meningitis with <b><i>Candida auris</i></b> Fungemia

Bacterial Meningitis as the First Presentation of Multiple Myeloma

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