An unusual presentation of primary cutaneous cryptococcosis

Longhitano, Sabrina; Peccerillo, Francesca; Odorici, Giulia; Bigi, Laura; Pellacani, Giovanni

doi:10.1111/dth.12942

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…There is no typical cutaneous lesion of cryptococcosis, but skin involvement is typically characterized by various non-specific presentations (e.g., papules, pustules, nodules, abscesses, edema, panniculitis, and ulcers) and can be due to a primary infection or due to a secondary systemic hematogenous spread [8][9][10]. Therefore, once a diagnosis is established, the infection of the brain and lungs must be excluded [11].…”

Section: Discussionmentioning

confidence: 99%

Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak

Passerini¹,

Terzi²,

Piscaglia³

et al. 2020

Cureus

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We report the case of a 61-year-old patient with a history of prostate cancer affected by bone metastasis. He presented to our attention for ulcerous and necrotic cutaneous lesions unresponsive to antibiotics. The spread of cutaneous lesions and the onset of neurological symptoms suggested a cryptococcal disease, which was confirmed by lumbar puncture and cutaneous biopsy. We present the diagnostic and therapeutic approach to this case.

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Section: Discussionmentioning

confidence: 99%

Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak

Passerini¹,

Terzi²,

Piscaglia³

et al. 2020

Cureus

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“…[1][2][3] Cutaneous infections are the third most common clinical manifestation of cryptococcosis, and these patients can present with various skin aberrations such as, papules, nodules, tumors, ulcerations, ecchymoses, pustules, abscesses and granulomas. [4][5][6][7] Early identification of polymorphic skin manifestations and treatment are essential for an effective prognosis of the infection. This condition can be divided into primary and secondary cutaneous cryptococcosis.…”

Section: Introductionmentioning

confidence: 99%

Mediastinal Small Cell Carcinoma with Primary Cutaneous Cryptococcosis: A Rare Case Report

Chai

Lei

et al. 2021

IDR

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Cutaneous cryptococcosis, an infectious disease resulting from Cryptococcus neoformans, primarily affects immunodeficient individuals. Here, we report a case of mediastinal small cell carcinoma (MSCC) complicated with multiple skin and soft tissue infections mimicking erysipelas and cellulitis. Antibiotics for bacteria were ineffective and a culture of pus from the infected areas revealed Cryptococcus neoformans in this patient. The absence of any evidence indicative of systemic cryptococcal infection leads to a final diagnosis of primary cutaneous cryptococcosis (PCC). Following two weeks of fluconazole at 400 mg/day and 200 mg/day for the subsequent three months, combined with incision, irrigation and drainage, the wound gradually healed. An analysis and discussion of the clinical features of this patient are presented. This case alerts clinicians as to the possibility of Cryptococcus neoformans in patients with advanced malignant tumors complicated with multiple skin and soft tissue infections. While a timely diagnosis and treatment of PCC in this patient resulted in a favorable outcome, the patient succumbed to the malignant tumor at six months post-discharge.

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“…PCC occurs as primary and secondary forms. Primary form mainly results from direct skin trauma and aberrations such as, papules, nodules, tumors, ulcerations, ecchymoses, pustules, abscesses and granulomas (3,13,17). Secondary PCC a more common type spreads from the brain, lung and other parts of the body.…”

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confidence: 99%

Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)

Kheirandish

Alidadi

Azizi

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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A 2-year-old Asian Houbara bustard was presented with a solitary well-defined, firm cutaneous mass on the hock region. Grossly, the mass protruded from the surface was located on the hairless and unpigmented areas of the right hock joint with ulceration and dried hemorrhagic foci. On microscopic examination, ulceration, hemorrhage, as well as hyperkeratosis were observed. Large round, oval to polygonal neoplastic cells extended into the dermis were arranged to form cords, trabeculae, islands or glandular-like structures without keratin pearls. These pseudoglandular structures were composed of pseudolumina containing acantholytic and detached tumor cells. Necrosis of the neoplastic cells was accompanied by infiltration of inflammatory cells particularly heterophils. Unlike pleomorphic tumor cells, mitotic count was almost frequent. No evidence of other abnormalities and tumor metastasis was found. These gross and microscopic features appeared to be suggestive of a rare histologic variant of squamous cell carcinoma (SCC), acantholytic SCC.

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An unusual presentation of primary cutaneous cryptococcosis

Cited by 4 publications

References 8 publications

Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak

Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak

Mediastinal Small Cell Carcinoma with Primary Cutaneous Cryptococcosis: A Rare Case Report

Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)

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