An Unusual Presentation of Wegener’s Granulomatosis with Otologic Symptoms and Unilateral Parotid Gland Enlargement

Chouhan, Anant; Kulhari, Mohan; Amisha, B; Kasliwal, Neeraj

doi:10.1007/s12070-015-0941-5

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Moreover, parotid involvement in vasculitis is rare. [12][13][14][15][16][17][18][19][20][21] Thus, the relationship between salivary gland involvement and vasculitis remains unclear. Additionally, the patient had a lacrimal gland lesion, which has been reported in patients with vasculitis.…”

Section: Discussionmentioning

confidence: 99%

“…Table 2 presents the previously reported cases of GPA with salivary gland involvement. [8][9][10][11][12][13][14][15][16][17][18][19][20][21] GPA with periaortitis was not reported in any of these case reports. Table 3 lists the previously reported cases of GPA with periaortitis.…”

Section: Discussionmentioning

confidence: 99%

“…Chouhan A [21] 51 M Table 3 Cases of granulomatosis with polyangiitis with periaortitis involvement.…”

Section: Pr3-anca Skin 2019mentioning

confidence: 99%

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Vasculitis mimicking immunoglobulin-G4-related disease with involvement of the submandibular and lacrimal glands and periaortitis: A case report

Odaka

Takahashi

et al. 2023

Medicine

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Introduction: Vasculitis does not usually induce glandular tissue lesions. Herein, we present a case of vasculitis with a distribution similar to that of immunoglobulin-G4-related disease (IgG4-RD), including that of the submandibular and lacrimal glands, and periaortitis. Case report: A 70-year-old man presented with shortness of breath. Laboratory findings revealed an IgG4 level of 191 mg/dL, negative antineutrophil cytoplasmic antibody test, and C-reactive protein level of 8.33 mg/dL. Magnetic resonance imaging of the head and computed tomography of the neck revealed bilaterally enlarged submandibular and lacrimal glands. Neck-to-pelvis computed tomography revealed bilateral infiltrative shadows in the lower lobes of both lungs, mass shadows in both lungs, and periaortitis of the abdominal aorta extending to the common iliac artery. Thus, the patient was diagnosed with IgG4-related respiratory disease and periaortitis/periarteritis. Prednisolone was administered at a dose of 35 mg (0.6 mg/kg daily). The dose was gradually tapered while observing the effects of the treatment. Imaging findings indicated an improvement and the C-reactive protein and IgG4 levels decreased, indicating a successful treatment course. However, after reexamination of the pathological findings, the diagnosis changed from IgG4-RD to vasculitis. One year after treatment initiation, the patient symptoms have stabilized. Conclusion: Vasculitis can present with lesions and pathological findings similar to those of IgG4-RD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vasculitis mimicking immunoglobulin-G4-related disease with involvement of the submandibular and lacrimal glands and periaortitis: A case report

Odaka

Takahashi

et al. 2023

Medicine

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“…The symptoms of the SG in WG may manifest as a unilateral or bilateral increase in the volume of one or more of the major SG, night sweats, or arthralgia. Paralysis of the facial nerve can arise if the parotid gland is involved (Almouhawis et al, 2013;Chouhan et al, 2019).…”

Section: Salivary Gland Disorders Associated With Systemic Pathologiesmentioning

confidence: 99%

Characterization of Salivary Gland Pain: A Review of the Literature

Mancilla,

Iturriaga,

Muñoz

et al. 2023

Int. J. Morphol.

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The salivary glands in pathological conditions produce countless different clinical presentations, and due to their complex neuroanatomy, their pain symptoms vary widely. However, in the literature to date, few studies characterize salivary gland pain. The aim of this study was to conduct a literature review concerning the clinical characteristics of pain in various salivary gland pathologies. A literature review was done through a systematic search of scientific articles in the Web of Science (WoS), MEDLINE, Scopus, and Elton B. Stephens Company (EBSCO) databases. The free terms "salivary gland", "parotid gland", "submaxillary gland", "sublingual gland", and "pain" were used along with the Boolean operators OR and AND. The search yielded a total of 1896 articles, of which 60 fulfilled the inclusion criteria and were ultimately included in this review. It is described that pain is a nonspecific symptom of a glandular pathology and is characterized mainly by the location of the pain, which is correlated with the anatomical location of the affected salivary gland. Among the painful salivary gland pathologies, we found inflammatory disorders, including infections, obstructions, disorders secondary to hyposalivation; systemic autoimmune diseases; neoplasms, and neuropathic pain disorders. The diagnosis and management of salivary gland pain require knowledge of the causes and mechanisms of the pain, and it is to recognize the signs and symptoms of salivary gland disorders to be able to diagnose and treat them.

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“…The inflammatory destructive lesions may develop in any organ. The evolution of GPA can be rapid and aggressive, and its mortality rate is 82% within 1 year when left untreated[ 1 , 2 ]. The classical clinical triad of GPA includes the upper respiratory tract, lower respiratory tract, and renal involvement[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report

Li¹,

Liu²,

Yan³

et al. 2021

WJCC

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BACKGROUND Granulomatosis with polyangiitis is a necrotizing inflammation of small and medium-sized vessels accompanied by formation of granuloma, involvement of primary granulomatous upper and lower respiratory tracts, glomerulonephritis, and vasculitis of small vessels. CASE SUMMARY Herein, we described a case of a 52-year-old man admitted with pulmonary nodules and high fever. Autoantibody workup revealed that the patient was positive for c-anti-neutrophil cytoplasmic antibodies and proteinase-3 anti-neutrophil cytoplasmic antibodies. Pulmonary biopsies revealed a local granulomatous structure. The patient received therapy with methylprednisolone and intravenous immunoglobulin, and his clinical symptoms improved. CONCLUSION Intravenous immunoglobulin may act on granulomatosis with polyangiitis similar to immunosuppressants.

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An Unusual Presentation of Wegener’s Granulomatosis with Otologic Symptoms and Unilateral Parotid Gland Enlargement

Cited by 6 publications

References 9 publications

Vasculitis mimicking immunoglobulin-G4-related disease with involvement of the submandibular and lacrimal glands and periaortitis: A case report

Vasculitis mimicking immunoglobulin-G4-related disease with involvement of the submandibular and lacrimal glands and periaortitis: A case report

Characterization of Salivary Gland Pain: A Review of the Literature

Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report

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