An Unusual Reaction to Combined Librium-Barbiturate Therapy

Transitory procaine-induced Parkinsonism

“…Chlordiazepoxide given alone, even in large amounts, elicited but few and very mild extrapyramidal symptoms (Gjerris, 1966); however, when given in combination with other psychotropic drugs, neurological deficits have been observed (Kane, and Taylor, 1963;Kane and McCurdy, 1964). In the present case the cerebral affection may be explained by interaction between chlordiazepoxide, meprobamate, barbiturate, and procaine in a predisposed subject.…”