An unusual sesquiterpene coumarin from the seeds of <i>Ferula sinkiangensis</i>

Li, Guang-Zhi; Wang, Junchi; Li, Xiaojin; Cao, Li; Gao, Li; Lv, Na; Si, Jianmin

doi:10.1080/10286020.2016.1168813

Cited by 21 publications

(17 citation statements)

References 10 publications

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“…Raw and dried Xinjiang, China, Asia (Zhang and Hu, 1987;Yang et al, 2006;Xiaojin and Jiang Lin, 2007;Yang et al, 2007;Zhang et al, 2015;Li et al, 2016;Xing et al, 2017) F. teterrima Kar. & Kir.…”

Section: Country Flora Endemic/indigenous Speciesmentioning

confidence: 99%

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Mohammadhosseini

Venditti

Sarker

et al. 2019

Industrial Crops and Products

129

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This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-resin (OGR) and the non-volatile fractions obtained from several endemic and indigenous Ferula species is also reported. A special emphasis is placed on their unusual components, i.e. sulfur-containing volatiles from the EOs and the new phytochemicals with mixed biogenetic origins. More than 180 chemical constituents (excluding common essential oils components), including sulfur-containing metabolites, terpenoids, coumarins, sesquiterpene coumarins, etc., as both aglycones and glycosides, are reported, along with their occurrence and biological activities when available. A large number of new secondary metabolites, belonging to different classes of natural products possessing interesting biological activities, from the antiproliferative to the anti-inflammatory to the neuroprotective ones, among the others, have been recently found in the Ferula genus. Several of these phytochemicals are exclusive to this genus; therefore may be considered chemotaxonomic markers. All these aspects are extensively discussed in this review.

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Section: Country Flora Endemic/indigenous Speciesmentioning

confidence: 99%

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Mohammadhosseini

Venditti

Sarker

et al. 2019

Industrial Crops and Products

129

View full text Add to dashboard Cite

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“…Ferula is a rich source of biologically active compounds, such as sesquiterpenes, coumarin derivatives, disulfide compounds, and aromatic lactones. Extracts and metabolites from Ferula possess important biological properties, including anti-inflammatory [ 21 ], antiviral [ 22 ], anticancerous [ 23 ], antidiabetic [ 24 ], and anti-bacterial [ 25 ] properties. The most common sesquiterpene in non-toxic chemotypes of Ferula L. is ferutinin (FER), which is commonly extracted from the roots, leaves, and rhizomes of plants [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes

Maiuolo

Bava

Carresi

et al. 2021

IJMS

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In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, the genus Ferula L. is one of the most representative, and ferutinin, the most common sesquiterpene, is extracted from the leaves, rhizome, and roots of this plant. As reported in the scientific literature, ferutinin possesses antioxidant and anti-inflammatory properties, as well as valuable estrogenic properties. Neurodegenerative and demyelinating diseases are devastating conditions for which a definite cure has not yet been established. The mechanisms involved in these diseases are still poorly understood, and oxidative stress is considered to be both a key modulator and a common denominator. In the proposed experimental system, co-cultured human neurons (SH-SY5Y) and human oligodendrocytes (MO3.13) were treated with the pro-inflammatory agent lipopolysaccharide at a concentration of 1 μg/mL for 24 h or pretreated with ferutinin (33 nM) for 24 h and subsequently exposed to lipopolysaccharide 1 μg/mL for 24 h. Further studies would, however, be needed to establish whether this natural compound can be used as a support strategy in pathologies characterized by progressive inflammation and oxidative stress phenomena.

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“…Previous phytochemical studies of genus Ferula mainly focused on sesquiterpenes and sesquiterpene coumarins, 20,21 and compounds such as sesquiterpene coumarins, steroidal esters and disulphide have been found from F. sinkiangensis. [22][23][24][25] However, the constituents of phenylpropanoid derivatives rarely reported in recent years. In this study, four new phenylpropanoid derivatives, Sinkiangenone A-D (1-2, 4-5), together with eleven known compounds (3,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were isolated from the resin of F. sinkiangensis.…”

Section: Introductionmentioning

confidence: 99%