An unusual variant of familial preexcitation

Vidaillet, Humberto; Burton, Claude S.; Ramirez, Norman M.; Gilbert, M. R.; Behar, Victor S.; Hackel, Donald B.; German, Lawrence D.

doi:10.1016/0002-9149(87)90822-8

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Linkage to nine other loci (D7S495, TCRB, D7S498, D7S688, D7S505, D7S642, D7S636, D7S483, and D7S550) was then assessed (Table II). The maximum two-point LOD score, detected with locus D7S505, was 7.80 at a recombination fraction (8) of 0.0 indicating odds of > 60,000,000 to 1 that the locus responsible for disease in Family AS is on chromosome 7q3 (30). The physical location of chromosome 7 anchor marker TCRB places the disease locus at 7q35-7q36 (27).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

MacRae¹,

Ghaisas²,

Kass³

et al. 1995

J. Clin. Invest.

192

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We have mapped a disease locus for Wolff-Parkinson-White syndrome (WPW) and familial hypertrophic cardiomyopathy (FHC) segregating in a large kindred to chromosome 7 band q3. Although WPW syndrome and FHC have been observed in members of the same family in prior studies, the relationship between these two diseases has remained enigmatic. A large family with 25 surviving individuals who are affected by one or both of these conditions was studied. The disease locus is closely linked to loci D7S688, D7S505, and D7S483 (maximum two point LOD score at D7S505 was 7.80 at 0 = 0). While four different FHC loci have been described this is the first locus that can be mutated to cause both WPW and/or FHC. (J. Clin. Invest. 1995. 96:1216-1220

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Section: Resultsmentioning

confidence: 99%

“…While most affected individuals appear to be sporadic, screening studies have suggested that at least 3% of probands have a symptomatic affected first degree relative ( 1). Reports of familial WPW have demonstrated an autosomal dominant mode of inheritance (2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

MacRae¹,

Ghaisas²,

Kass³

et al. 1995

J. Clin. Invest.

192

View full text Add to dashboard Cite

show abstract

“…Since Öhnell reported familial WPW syndrome in 2 kindreds in 1944, 1 several other studies of the familial occurrence of WPW syndrome have been reported. [2][3][4][5][6][7] These studies suggested that WPW syndrome may be caused by genetic defects, based on the observations that WPW syndrome developed in infancy or childhood and in multiple generations in certain families.…”

Section: Discussionmentioning

confidence: 99%